A Fungal Sterylglucosidase at the Intersection of Virulence, Host Immunity, and Therapeutic Development.
A Fungal Sterylglucosidase at the Intersection of Virulence, Host Immunity, and Therapeutic Development.
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作者：
人类真菌感染（真菌病）在高危人群中引起显著的发病率和死亡率。当代抗真菌疗法严重依赖于三类抗真菌药物，迄今为止，没有真菌疫苗用于临床治疗侵袭性真菌病。与真菌疫苗开发有关的知识的一个主要空白是确定免疫功能低下个体的保护性免疫的持久机制。最近对新型隐球菌和烟曲霉的研究发现了一种真菌甾醇葡萄糖苷酶，这种酶对小鼠真菌病的发病和毒力至关重要。令人惊讶的是，在多种免疫功能低下的真菌病小鼠模型中，缺乏这种甾醇葡萄糖苷酶的真菌菌株也能诱导大量免疫介导的保护，抵抗随后野生型菌株的攻击。在这里，我将讨论这些令人兴奋和有影响力的结果的含义和未来方向。
Human fungal infections (mycoses) cause significant morbidity and mortality in high-risk populations. Contemporary antifungal therapies rely heavily on three classes of antifungal drugs, and to date, no fungal vaccine is in clinical use for invasive mycosis. A major gap in knowledge related to fungal vaccine development is identifying lasting mechanisms of protective immunity in immunocompromised individuals. Recent studies in Cryptococcus neoformans and now Aspergillus fumigatus have identified a fungal sterylglucosidase essential for pathogenesis and virulence in murine models of mycoses. Fungal strains deficient in this sterylglucosidase can surprisingly also induce substantial immune-mediated protection against subsequent challenge with wild-type strains in multiple immunocompromised murine models of mycoses. Here, I discuss the implications and future directions of these exciting and impactful results.
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影响因子：
5.7
作者：
Normile TG;Rella A;Del Poeta M
通讯作者：
Del Poeta M
影响因子：
6.7
作者：
Gravelat FN;Beauvais A;Liu H;Lee MJ;Snarr BD;Chen D;Xu W;Kravtsov I;Hoareau CM;Vanier G;Urb M;Campoli P;Al Abdallah Q;Lehoux M;Chabot JC;Ouimet MC;Baptista SD;Fritz JH;Nierman WC;Latgé JP;Mitchell AP;Filler SG;Fontaine T;Sheppard DC
通讯作者：
Sheppard DC
影响因子：
16.6
作者：
Pereira de Sa N;Taouil A;Kim J;Clement T;Hoffmann RM;Burke JE;Rizzo RC;Ojima I;Del Poeta M;Airola MV
通讯作者：
Airola MV
DOI：
10.5588/ijtld.21.0053
发表时间：
2021-07-01
影响因子：
4
作者：
Denning, D. W.
通讯作者：
Denning, D. W.
影响因子：
4.4
作者：
Cenci, E;Mencacci, A;Romani, L
通讯作者：
Romani, L