Assessing the Genetic Correlations Between Blood Plasma Proteins and Osteoporosis: A Polygenic Risk Score Analysis.
Assessing the Genetic Correlations Between Blood Plasma Proteins and Osteoporosis: A Polygenic Risk Score Analysis.
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评估血浆蛋白与骨质疏松症之间的遗传相关性：多基因风险评分分析
DOI：
10.1007/s00223-018-0483-4
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发表时间：
2019-03
影响因子：
4.2
通讯作者：
Deng HW
中科院分区：
文献类型：
--
作者：
Liang X;Du Y;Wen Y;Liu L;Li P;Zhao Y;Ding M;Cheng B;Cheng S;Ma M;Zhang L;Shen H;Tian Q;Guo X;Zhang F;Deng HW
骨质疏松症是一种常见的代谢性骨病。全球血浆蛋白对骨质疏松症风险的影响现在仍然难以捉摸。我们进行了一个大规模的多基因风险评分（PRS）分析，以评估血浆蛋白对2286名白人，包括558名男性和1728名女性骨质疏松症的发展的潜在影响。使用Hologic 4500 W DXA测量尺桡骨、髋部和脊柱的骨密度（BMD）和骨面积。将年龄、性别、身高和体重作为协变量调整BMD/骨面积值。使用Affyscore Human SNP Array 6.0对2286名高加索受试者进行全基因组SNP基因分型。267个血浆蛋白相关SNP位点及其遗传效应是从最近发表的全基因组关联研究（GWAS）中获得的，该研究使用了高度多重的基于适体的亲和蛋白质组学平台。根据2286例白人受试者的基因型数据，通过PLINK软件计算研究受试者对每种血浆蛋白的多遗传风险评分（PRS）。采用R.此外，还通过Pearson相关分析进行了性别特异性分析。本研究分析了267种血浆蛋白。对于BMD，我们观察到41种蛋白质与BMD之间的相关信号，主要包括全身总BMD与因子H（p值= 9.00 × 10−3）、全身总BMD与BGH 3（p值= 1.40 × 10−2）、脊柱总BMD与IGF-I（p值= 2.15 × 10−2）和脊柱总BMD与SAP（p值= 3.90 × 10−2）。至于骨面积，观察到45种血浆蛋白与骨面积之间的关联证据，如铁蛋白与脊柱面积（p值= 1.90 × 10−2），C4与髋关节面积（p值= 1.25 × 10−2），血红蛋白与右尺桡骨面积（p值= 2.70 × 10−2）。我们的研究结果表明，血浆蛋白对BMD/骨面积的变化有一定的影响，并确定了几个骨质疏松症的候选血浆蛋白。
Osteoporosis is a common metabolic bone disease. The impact of global blood plasma proteins on the risk of osteoporosis remains elusive now. We performed a large-scale polygenic risk score (PRS) analysis to evaluate the potential effects of blood plasma proteins on the development of osteoporosis in 2286 Caucasians, including 558 males and 1728 females. Bone mineral density (BMD) and bone areas at ulna & radius, hip, and spine were measured using Hologic 4500W DXA. BMD/bone areas values were adjusted for age, sex, height, and weight as covariates. Genome-wide SNP genotyping of 2286 Caucasian subjects was performed using Affymetrix Human SNP Array 6.0. The 267 blood plasma proteins-associated SNP loci and their genetic effects were obtained from recently published genome-wide association study (GWAS) using a highly multiplexed aptamer-based affinity proteomics platform. The polygenetic risk score (PRS) of study subjects for each blood plasma protein was calculated from the genotypes data of the 2286 Caucasian subjects by PLINK software. Pearson correlation analysis of individual PRS values and BMD/bone area value was performed using R. Additionally, gender-specific analysis also was performed by Pearson correlation analysis. 267 blood plasma proteins were analyzed in this study. For BMD, we observed association signals between 41 proteins and BMD, mainly including whole body total BMD versus Factor H (pvalue = 9.00 × 10−3), whole body total BMD versus BGH3 (pvalue = 1.40 × 10−2), spine total BMD versus IGF-I (pvalue = 2.15 × 10−2), and spine total BMD versus SAP (pvalue = 3.90 × 10−2). As for bone areas, association evidence was observed between 45 blood plasma proteins and bone areas, such as ferritin versus spine area (pvalue = 1.90 × 10−2), C4 versus hip area (pvalue = 1.25 × 10−2), and hemoglobin versus right ulna and radius area (pvalue = 2.70 × 10−2). Our study results suggest the modest impact of blood plasma proteins on the variations of BMD/bone areas, and identify several candidate blood plasma proteins for osteoporosis.
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影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
4
作者：
Cesari, M;Pahor, M;Ferrucci, L
通讯作者：
Ferrucci, L
影响因子：
5.8
作者：
Langlois, JA;Rosen, CJ;Kiel, DP
通讯作者：
Kiel, DP
DOI：
10.1016/s0304-4165(02)00286-6
发表时间：
2002-08-15
影响因子：
3
作者：
Ohno, S;Doi, T;Tanne, K
通讯作者：
Tanne, K
影响因子：
11.1
作者：
JOHANSSON, AG;BURMAN, P;LJUNGHALL, S
通讯作者：
LJUNGHALL, S