Multiple conformational selection and induced fit events take place in allosteric propagation.
Multiple conformational selection and induced fit events take place in allosteric propagation.
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DOI：
10.1016/j.bpc.2013.10.002
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发表时间：
2014-03
影响因子：
3.8
通讯作者：
Tsai CJ
中科院分区：
文献类型：
--
作者：
Nussinov R;Ma B;Tsai CJ
我们在结合过程中观察到单个构象选择事件的事实并不一定意味着仅发生单个构象选择事件，尽管这是常见的假设。在这里，我们建议构象选择不是在给定的结合/变构事件中发生一次，而是在变构途径的每一步中发生。这种观点概括了构象选择，并使其也适用于其他变构事件，例如翻译后修饰（PTM）和光子吸收。与结合类似，在传播途径的每个步骤中，构象选择与诱导拟合相结合，从而优化了相互作用。因此，与结合一样，PTM 和光诱导的变构效应不仅与群体迁移有关，而且与群体迁移有关。但也与构象选择有关。构象选择和群体迁移同时发生。
The fact that we observe a single conformational selection event during binding does not necessarily mean that only a single conformational selection event takes place, even though this is the common assumption. Here we suggest that conformational selection takes place not once in a given binding/allosteric event, but at every step along the allosteric pathway. This view generalizes conformational selection and makes it applicable also to other allosteric events, such as post-translational modifications (PTMs) and photon absorption. Similar to binding, at each step along a propagation pathway, conformational selection is coupled with induced fit which optimizes the interactions. Thus, as in binding, the allosteric effects induced by PTMs and light relate not only to population shift; but to conformational selection as well. Conformational selection and population shift take place conjointly.
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DOI：
10.1016/j.str.2009.06.008
发表时间：
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期刊：
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影响因子：
--
作者：
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影响因子：
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发表时间：
2005-11-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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