Brain lesions disrupting addiction map to a common human brain circuit.
Brain lesions disrupting addiction map to a common human brain circuit.
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DOI：
10.1038/s41591-022-01834-y
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发表时间：
2022-06
期刊：
影响因子：
82.9
通讯作者：
Fox, Michael D.
中科院分区：
文献类型：
--
作者：
Joutsa, Juho;Moussawi, Khaled;Siddiqi, Shan H.;Abdolahi, Amir;Drew, William;Cohen, Alexander L.;Ross, Thomas J.;Deshpande, Harshawardhan U.;Wang, Henry Z.;Bruss, Joel;Stein, Elliot A.;Volkow, Nora D.;Grafman, Jordan H.;van Wijngaarden, Edwin;Boes, Aaron D.;Fox, Michael D.
药物成瘾是一种公共卫生危机，迫切需要新的治疗方法。在极少数情况下，局部脑损伤可能导致成瘾缓解。这些病例可用于鉴定神经调节的治疗靶点。我们分析了两组在局灶性脑损伤时吸烟成瘾的患者（队列1 n = 67;队列2 n = 62）。将病变位置映射到脑图谱，并使用人类连接体数据（n = 1，000）计算功能上连接到每个病变位置的脑网络。与成瘾缓解的协会进行了鉴定。使用一个独立队列的局灶性脑损伤和酒精成瘾风险评分（n = 186）的患者进行了评估。通过与其他37个神经心理学变量进行比较来评估特异性。破坏吸烟成瘾的病变发生在许多不同的大脑位置，但其特征是大脑连接的特定模式。这种模式涉及到与背侧扣带、外侧前额叶皮层和颞叶的正连接，以及与内侧前额叶和颞叶皮层的负连接。这种回路在独立的病变队列中是可重复的，与降低的酒精成瘾风险相关，并且特定于成瘾指标。与成瘾缓解的连接特征最匹配的枢纽是扣带回旁、左额盖和内侧额极皮层。我们的结论是，大脑病变破坏成瘾映射到一个特定的人类大脑回路，在这个回路中的枢纽提供了可测试的治疗性神经调节的目标。导致成瘾缓解的病变发生在多个不同的大脑位置，但映射到特定的大脑回路。
Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to addiction remission. These cases may be used to identify therapeutic targets for neuromodulation. We analyzed two cohorts of patients addicted to smoking at the time of focal brain damage (cohort 1 n = 67; cohort 2 n = 62). Lesion locations were mapped to a brain atlas and the brain network functionally connected to each lesion location was computed using human connectome data (n = 1,000). Associations with addiction remission were identified. Generalizability was assessed using an independent cohort of patients with focal brain damage and alcohol addiction risk scores (n = 186). Specificity was assessed through comparison to 37 other neuropsychological variables. Lesions disrupting smoking addiction occurred in many different brain locations but were characterized by a specific pattern of brain connectivity. This pattern involved positive connectivity to the dorsal cingulate, lateral prefrontal cortex, and insula and negative connectivity to the medial prefrontal and temporal cortex. This circuit was reproducible across independent lesion cohorts, associated with reduced alcohol addiction risk, and specific to addiction metrics. Hubs that best matched the connectivity profile for addiction remission were the paracingulate gyrus, left frontal operculum, and medial fronto-polar cortex. We conclude that brain lesions disrupting addiction map to a specific human brain circuit and that hubs in this circuit provide testable targets for therapeutic neuromodulation. Lesions resulting in addiction remission occur in multiple different brain locations but map to a specific brain circuit.
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影响因子：
5.7
作者：
Karnath HO;Sperber C;Rorden C
通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.1819978116
发表时间：
2019-04-30
影响因子：
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作者：
Hu, Yuzheng;Salmeron, Betty Jo;Yang, Yihong
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