Interactions between non-immune host cells and the immune system during periodontal disease: role of the gingival keratinocyte.
Interactions between non-immune host cells and the immune system during periodontal disease: role of the gingival keratinocyte.
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牙周病期间非免疫宿主细胞与免疫系统之间的相互作用：牙龈角质形成细胞的作用。
DOI：
10.1177/10454411980090030301
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
O. Barsotti
中科院分区：
文献类型：
--
作者：
G. Suchett;J. Morrier;O. Barsotti
牙周病和炎性皮肤病，如牛皮癣，其特征在于分别在牙龈和皮肤的上皮细胞层下紧接着的致密炎性浸润物的积累。皮肤科医生越来越意识到表皮角质形成细胞可能通过分泌大量促炎细胞因子和表达各种粘附分子而促进炎症性疾病的进展。在银屑病皮损中，现在认为表皮角质形成细胞也可作为抗原呈递细胞，并直接参与T细胞克隆的超抗原活化，其中一些可启动、促进或维持疾病过程。虽然宿主反应在牙周病中的作用已经被广泛研究了多年，但对牙龈角质形成细胞对炎症反应的贡献知之甚少。在这篇综述中讨论了现有的已发表的信息，我们认为，像它的表皮对应，牙龈角质形成细胞可能积极参与牙周病的发病机制。
Periodontal disease and inflammatory dermatoses, such as psoriasis, are characterized by the accumulation of dense inflammatory infiltrates immediately beneath the epithelial cell layer of the gingiva and skin, respectively. Dermatologists are increasingly aware that the epidermal keratinocyte probably contributes to inflammatory disease progression by secreting a number of pro-inflammatory cytokines and expressing various adhesion molecules. In psoriatic lesions, it is now believed that epidermal keratinocytes may also act as antigen-presenting cells and participate directly in the superantigenic activation of T-cell clones, some of which may initiate, contribute to, or maintain the disease process. Although the role of the host response in periodontal disease has been extensively studied over the years, very little is known about the contribution of the gingival keratinocyte to the inflammatory response. The available published information is discussed in this review, and we suggest that, like its epidermal counterpart, the gingival keratinocyte may participate actively in the pathogenesis of periodontal disease.
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DOI：
--
发表时间：
1991
期刊：
The American journal of pathology
影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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