Representation of Latinos and Blacks in screening for and enrollment into preventive HIV vaccine trials in New York City.
Representation of Latinos and Blacks in screening for and enrollment into preventive HIV vaccine trials in New York City.
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代表拉丁裔和黑人参与纽约市预防性艾滋病毒疫苗筛查和招募试验。
DOI：
10.1016/j.vaccine.2015.09.091
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发表时间：
2015
期刊：
影响因子：
5.5
通讯作者：
Sobieszczyk,MagdalenaE
中科院分区：
文献类型：
--
作者：
Ellman,TanyaM;Hawkins,Kellie;Benitez,Jorge;Negron,Ramon;Chang,Steven;Palmer,Steven;Robertson,Verna;Chiasson,MaryAnn;Sobieszczyk,MagdalenaE
简介在美国，拉丁裔和黑人受艾滋病毒/艾滋病的影响尤为严重，但在艾滋病毒疫苗试验中的代表性不足。我们评估了 2009-2012 年在纽约市进行的预防性 HIV 疫苗试验中黑人和拉丁裔的筛查和招募情况。方法对四项预防性 1 期和 2 期 HIV 疫苗试验的 18-50 岁男性和变性女性筛查进行了回顾性分析。对人口统计、招聘、行为/医疗资格数据和筛查结果进行了检查。为了确定与入学相关的因素，我们进行了多变量逻辑回归分析。结果在 6077 名提供联系信息的人中，2536 人完成了电话预筛选。 96 人（占招聘联系人的 1.6%）报名。拉丁裔占招聘联系人的 35.7%，但在注册人数中占 17.7%，而黑人则分别占 22.5% 和 32.3%。在所有拉丁裔中，近三分之一因未受割礼而被排除在外，这是多项研究的资格标准。在对可能符合资格的潜在参与者进行多变量分析时，控制年龄和招募方法，拉丁裔比白人参加预防性 HIV 疫苗试验的可能性更低（aOR 0.52，95% CI 0.28–0.95），而黑人则与白人一样参加预防性 HIV 疫苗试验（aOR 0.99，95% CI 0.59–1.67）。在控制年龄和种族/民族的情况下，通过印刷广告、社交媒体/互联网、推荐和其他方式招募的个人比通过面对面外展招募的个人更有可能参加。结论有针对性的外展导致拉丁裔和黑人大量纳入，其中黑人占这些预防性艾滋病毒疫苗试验注册人数的近三分之一。然而，与白人相比，拉丁裔入学的可能性较小。包皮环切状况作为一个资格标准在一定程度上解释了这一点，但需要进一步研究来解决拉丁裔决定不参加预防性艾滋病毒疫苗试验的原因。
IntroductionIn the United States, Latinos and Blacks are disproportionately affected by HIV/AIDS, but have been underrepresented in HIV vaccine trials. We assessed screening and enrollment of Blacks and Latinos for preventive HIV vaccine trials conducted in New York City, 2009–2012.MethodsA retrospective analysis was conducted among 18–50 year old men and transgender women screening for four preventive phase 1 and 2 HIV vaccine trials. Demographic, recruitment, and behavioral/medical eligibility data and outcome of screening were examined. To determine factors associated with enrollment, a multivariable logistic regression analysis was performed.ResultsAmong 6077 individuals who provided contact information, 2536 completed a phone pre-screen. 96 (1.6% of recruitment contacts) enrolled. Latinos were 35.7% of recruitment contacts, but 17.7% of those enrolled, whereas Blacks were 22.5% and 32.3%, respectively. Among all Latinos, nearly one third were excluded for being uncircumcised, an eligibility criterion for several studies. In multivariable analysis among potentially eligible potential participants, controlling for age and recruitment method, Latinos were less likely than Whites to enroll in a preventive HIV vaccine trial (aOR 0.52, 95% CI 0.28–0.95) whereas Blacks were as likely as Whites (aOR 0.99, 95% CI 0.59–1.67). Individuals recruited through print advertisements, social media/internet, referral, and other modes were more likely to enroll compared to those recruited through in-person outreach, controlling for age and race/ethnicity.ConclusionsTargeted outreach has led to substantial inclusion of Latinos and Blacks, with Blacks comprising almost a third of those enrolled in these preventive HIV vaccine trials. Latinos, however, were less likely to enroll compared to Whites. Circumcision status as an eligibility criterion partly accounts for this, but further studies are warranted to address the reasons Latinos decide not to participate in preventive HIV vaccine trials.
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DOI：
10.1080/09540120600872711
发表时间：
2007-01-01
影响因子：
1.7
作者：
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通讯作者：
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DOI：
10.1097/01.qai.0000152039.88422.ec
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DOI：
10.1097/01.qai.0000174655.63653.38
发表时间：
2005-12-15
影响因子：
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DOI：
10.1016/s0002-9629(15)40464-1
发表时间：
1999
期刊：
The American journal of the medical sciences
影响因子：
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DOI：
--
发表时间：
2006
期刊：
MedGenMed : Medscape general medicine
影响因子：
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作者：
Calderón,JoséL;Baker,RichardS;Fabrega,Horacio;Conde,JoséG;Hays,RonD;Fleming,Erik;Norris,Keith
通讯作者：
Norris,Keith