The structures of the mouse and human urocortin genes (Ucn and UCN).
The structures of the mouse and human urocortin genes (Ucn and UCN).
复制标题
小鼠和人类尿皮质素基因（Ucn 和 UCN）的结构。
DOI：
10.1006/geno.1998.5292
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Vale,WW
中科院分区：
文献类型：
--
作者：
Zhao,L;Donaldson,CJ;Smith,GW;Vale,WW
小鼠和人的尿皮质素基因（UCN和UCN，分别）已被分离，表征，并发现具有非常相似的结构。每个基因都有两个外显子，整个编码区位于第二个外显子，与相关肽促肾上腺皮质激素释放因子的基因一样。在每个尿皮质素启动子中鉴定了几个推定的转录因子结合位点，包括TATA盒、环AMP反应元件（CRE）、GATA结合位点和C/EBP结合位点以及Brn-2结合位点。对小鼠和人类基因的序列分析也揭示了在尿皮质素基因上游的5′区存在先前鉴定的基因Mpv 17。在PC 12细胞中瞬时转染尿皮质素报告质粒后的功能研究显示，尿皮质素启动子由阳性和阴性元件控制; CRE对于基础活性以及对毛喉素刺激的响应性是重要的。
The mouse and human urocortin genes (Ucn and UCN, respectively) have been isolated, characterized, and found to have very similar structures. Each has two exons, and the entire coding region is located in the second exon, as is the case for the gene of the related peptide, corticotropin-releasing factor. Several putative transcription factor-binding sites were identified in each of the urocortin promoters, including a TATA box, a cyclic AMP response element (CRE), GATA-binding sites, and a C/EBP-binding site as well as a Brn-2-binding site(s). Sequence analyses of the mouse and human genes also revealed the presence of a previously identified gene, Mpv17, in the 5′ region upstream of the urocortin gene. Functional studies following transient transfection of urocortin reporter plasmids in PC12 cells revealed that the urocortin promoter is controlled by both positive and negative elements; the CRE is important for basal activity as well as responsiveness to forskolin stimulation.
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作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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