Emerging links between homeostatic synaptic plasticity and neurological disease.
Emerging links between homeostatic synaptic plasticity and neurological disease.
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DOI：
10.3389/fncel.2013.00223
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发表时间：
2013-11-21
影响因子：
5.3
通讯作者：
Dickman D
中科院分区：
文献类型：
--
作者：
Wondolowski J;Dickman D
稳态信号系统是一种普遍存在的生物调节形式，已经在包括体温和渗透平衡在内的多种生理过程中进行了数百年的研究。然而，直到最近才将这一概念引入神经系统用于建立和维持稳定通信的兴奋性和抑制性电活动的研究中。突触是神经元调控的主要目标，过去15年的各种研究表明，这些细胞连接受到双向稳态控制。最近来自一系列不同系统和方法的工作揭示了稳态突触可塑性与各种看似不同的神经和精神疾病之间令人兴奋的新联系。其中包括自闭症谱系障碍、智力残疾、精神分裂症和脆性X综合征。虽然有缺陷的体内平衡信号可能导致疾病发病的分子机制尚不清楚，但在未来几年，利用遗传、成像、电生理和下一代测序方法的强大组合，可能会取得快速进展。重要的是，在细胞和分子水平上理解稳态突触可塑性可能会导致治疗这些疾病的新疗法的发展。在这篇综述中，我们将回顾最近的研究，这些研究表明突触后蛋白翻译、逆行信号和突触前功能的稳态控制可能与复杂神经和精神疾病的病因有关。
Homeostatic signaling systems are ubiquitous forms of biological regulation, having been studied for hundreds of years in the context of diverse physiological processes including body temperature and osmotic balance. However, only recently has this concept been brought to the study of excitatory and inhibitory electrical activity that the nervous system uses to establish and maintain stable communication. Synapses are a primary target of neuronal regulation with a variety of studies over the past 15 years demonstrating that these cellular junctions are under bidirectional homeostatic control. Recent work from an array of diverse systems and approaches has revealed exciting new links between homeostatic synaptic plasticity and a variety of seemingly disparate neurological and psychiatric diseases. These include autism spectrum disorders, intellectual disabilities, schizophrenia, and Fragile X Syndrome. Although the molecular mechanisms through which defective homeostatic signaling may lead to disease pathogenesis remain unclear, rapid progress is likely to be made in the coming years using a powerful combination of genetic, imaging, electrophysiological, and next generation sequencing approaches. Importantly, understanding homeostatic synaptic plasticity at a cellular and molecular level may lead to developments in new therapeutic innovations to treat these diseases. In this review we will examine recent studies that demonstrate homeostatic control of postsynaptic protein translation, retrograde signaling, and presynaptic function that may contribute to the etiology of complex neurological and psychiatric diseases.
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DOI：
10.1523/jneurosci.5465-11.2012
发表时间：
2012-06-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dickman DK;Tong A;Davis GW
通讯作者：
Davis GW
影响因子：
25
作者：
Chang, Michael C.;Park, Joo Min;Pelkey, Kenneth A.;Grabenstatter, Heidi L.;Xu, Desheng;Linden, David J.;Sutula, Thomas P.;McBain, Chris J.;Worley, Paul F.
通讯作者：
Worley, Paul F.
影响因子：
64.8
作者：
Davis, GW;Goodman, CS
通讯作者：
Goodman, CS
DOI：
10.1523/jneurosci.3077-12.2012
发表时间：
2012-09-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Blackman MP;Djukic B;Nelson SB;Turrigiano GG
通讯作者：
Turrigiano GG
影响因子：
1.4
作者：
Dursun, Fatma;Gueven, Ayla;Morris-Rosendahl, Deborah
通讯作者：
Morris-Rosendahl, Deborah