Rapid and quantitative chemical exchange saturation transfer (CEST) imaging with magnetic resonance fingerprinting (MRF).
Rapid and quantitative chemical exchange saturation transfer (CEST) imaging with magnetic resonance fingerprinting (MRF).
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DOI：
10.1002/mrm.27221
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发表时间：
2018-12
影响因子：
3.3
通讯作者：
Farrar CT
中科院分区：
文献类型：
--
作者：
Cohen O;Huang S;McMahon MT;Rosen MS;Farrar CT
To develop a fast magnetic resonance fingerprinting (MRF) method for quantitative chemical exchange saturation transfer (CEST) imaging. We implemented a CEST-MRF method to quantify the chemical exchange rate and volume fraction of the Nα-amine protons of L-arginine (L-Arg) phantoms and the amide and semi-solid exchangeable protons of in vivo rat brain tissue. L-Arg phantoms were made with different concentrations (25–100 mM) and pH (pH 4–6). The MRF acquisition schedule varied the saturation power randomly for 30 iterations (phantom: 0–6 μT; in vivo: 0–4 μT) with a total acquisition time of ≤2 minutes. The signal trajectories were pattern-matched to a large dictionary of signal trajectories simulated using the Bloch-McConnell equations for different combinations of exchange rate, exchangeable proton volume fraction, and water T1 and T2 relaxation times. The chemical exchange rates of the Nα-amine protons of L-Arg were significantly (p<0.0001) correlated with the rates measured with the Quantitation of Exchange using Saturation Power method. Similarly, the L-Arg concentrations determined using MRF were significantly (p<0.0001) correlated with the known concentrations. The pH dependence of the exchange rate was well fit (R2=0.9186) by a base catalyzed exchange model. The amide proton exchange rate measured in rat brain cortex (34.8±11.7 Hz) was in good agreement with that measured previously with the Water Exchange spectroscopy method (28.6±7.4 Hz). The semi-solid proton volume fraction was elevated in white (12.2±1.7%) compared to gray (8.1±1.1%) matter brain regions in agreement with previous magnetization transfer studies. CEST-MRF provides a method for fast, quantitative CEST imaging.
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DOI：
10.1016/j.jconrel.2014.02.005
发表时间：
2014-04-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Chan KW;Yu T;Qiao Y;Liu Q;Yang M;Patel H;Liu G;Kinzler KW;Vogelstein B;Bulte JW;van Zijl PC;Hanes J;Zhou S;McMahon MT
通讯作者：
McMahon MT
影响因子：
4.3
作者：
Li, Jikun;Feng, Xinxin;Oldfield, Eric
通讯作者：
Oldfield, Eric
影响因子：
3.3
作者：
Cohen O;Zhu B;Rosen MS
通讯作者：
Rosen MS
影响因子：
3.3
作者：
Chen, Liu Qi;Howison, Christine M.;Jeffery, Justin J.;Robey, Ian F.;Kuo, Phillip H.;Pagel, Mark D.
通讯作者：
Pagel, Mark D.
影响因子：
3.3
作者：
Cauley SF;Setsompop K;Ma D;Jiang Y;Ye H;Adalsteinsson E;Griswold MA;Wald LL
通讯作者：
Wald LL