Regulators of small GTPases.
Regulators of small GTPases.
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小 GTP 酶的调节剂。
DOI：
10.1002/9780470514450.ch9
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
H. Shirataki
中科院分区：
文献类型：
--
作者：
Y. Takai;K. Kaibuchi;Akira Kikuchi;Takuya Sasaki;H. Shirataki
小的GTP酶通过GDP/GTP交换反应从GDP结合的无活性形式转化为GTP结合的活性形式，该反应由GDP/GTP交换蛋白（GEPs）调节。我们发现了刺激性和抑制性GEPs，我们分别将其命名为GDP解离刺激因子（gds）和GDP解离抑制剂（gdi）。我们分离了Smg GDS、Rho GDI和Rab GDI，克隆了它们，并确定了它们的一级结构。这些GEPs在一组小的gtp酶上有活性：Smg GDS至少在K-Ras、Rap1/Smg21、Rho和Rac上有活性；GDI至少在Rac和Cdc42上；拉伯家族的大部分成员都有GDI。这些GEPs还有一个额外的功能，调节其底物小gtpase在膜和细胞质溶胶之间的易位。GEPs只与其底物小gtpase的翻译后修饰形式相互作用。
Small GTPases are converted from the GDP-bound inactive form to the GTP-bound active form by a GDP/GTP exchange reaction which is regulated by GDP/GTP exchange proteins (GEPs). We have found both stimulatory and inhibitory GEPs, which we have named GDP dissociation stimulators (GDSs) and GDP dissociation inhibitors (GDIs) respectively. We have isolated Smg GDS, Rho GDI and Rab GDI, cloned them, and determined their primary structures. These GEPs are active on a group of small GTPases: Smg GDS on at least K-Ras, Rap1/Smg21, Rho and Rac; Rho GDI on at least Rho, Rac and Cdc42; Rab GDI on most of the Rab family members. These GEPs have an additional function, regulating the translocation of their substrate small GTPases between the membrane and the cytosol. The GEPs interact only with the post-translationally modified form of their substrate small GTPases.
通过添加肉豆蔻酰化信号激活细胞原癌基因产物 p21Ras。
DOI：
10.1126/science.2648572
发表时间：
1989
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Buss,JE;Solski,PA;Schaeffer,JP;MacDonald,MJ;Der,CJ
通讯作者：
Der,CJ
影响因子：
56.9
作者：
KNAUS, UG;HEYWORTH, PG;BOKOCH, GM
通讯作者：
BOKOCH, GM