The polymer and materials science of the bacterial fimbriae Caf1.
The polymer and materials science of the bacterial fimbriae Caf1.
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DOI：
10.1039/d3bm01075a
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发表时间：
2023-11-07
影响因子：
6.6
通讯作者：
中科院分区：
文献类型：
--
作者：
菌毛是位于细菌表面的长丝状多聚蛋白结构。菌毛的生物合成和功能常常与致病性有关，几十年来一直是一个富有成效的研究课题。进化的压力确保了菌毛具有独特的结构和机械特性，这对细菌有利。这些特性也很难用众所周知的合成和天然纤维来设计，这就提出了一个有趣的问题：我们能否以有用的方式利用细菌菌毛的独特特性？最初的工作已经开始探索这个问题，通过使用荚膜抗原片段1（Caf 1），菌毛自然表达的鼠疫耶尔森氏菌。这些纤维已经进化成“保护”细菌免受感染宿主的免疫系统的影响，因此在本质上是相当生物惰性的。然而，Caf 1非常适合于结构诱变，其允许并入有用的生物活性功能和调节纤维的机械性质。其高产重组合成也确保了大量的聚合物可用于推动开发。这些有利的特征使得Caf 1成为基于细菌菌毛的新聚合物和材料开发的原型。在这里，我们涵盖了这一新领域的最新进展，并展望了这种有前途的生物聚合物的未来可能性。介绍了鼠疫菌表达的菌毛--荚膜抗原片段1（Capsular antigen fragment 1，Caf 1）的高分子材料研究进展。
Fimbriae are long filamentous polymeric protein structures located upon the surface of bacteria. Often implicated in pathogenicity, the biosynthesis and function of fimbriae has been a productive topic of study for many decades. Evolutionary pressures have ensured that fimbriae possess unique structural and mechanical properties which are advantageous to bacteria. These properties are also difficult to engineer with well-known synthetic and natural fibres, and this has raised an intriguing question: can we exploit the unique properties of bacterial fimbriae in useful ways? Initial work has set out to explore this question by using Capsular antigen fragment 1 (Caf1), a fimbriae expressed naturally by Yersina pestis. These fibres have evolved to ‘shield’ the bacterium from the immune system of an infected host, and thus are rather bioinert in nature. Caf1 is, however, very amenable to structural mutagenesis which allows the incorporation of useful bioactive functions and the modulation of the fibre's mechanical properties. Its high-yielding recombinant synthesis also ensures plentiful quantities of polymer are available to drive development. These advantageous features make Caf1 an archetype for the development of new polymers and materials based upon bacterial fimbriae. Here, we cover recent advances in this new field, and look to future possibilities of this promising biopolymer. Progress in revealing the rich polymer and materials science of Capsular antigen fragment 1 (Caf1), a bacterial fimbriae expressed by the bacterium Yersina pestis, is described.
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影响因子：
15
作者：
Taylor EL;Metcalf KJ;Carlotti B;Lai CT;Modica JA;Schatz GC;Mrksich M;Goodson T 3rd
通讯作者：
Goodson T 3rd
影响因子：
2.9
作者：
BRANDTS, JF;LIN, LN
通讯作者：
LIN, LN
影响因子：
5.6
作者：
Di Yu, Xiao;Fooks, Laura J.;Zavialov, Anton V.
通讯作者：
Zavialov, Anton V.
影响因子：
5.4
作者：
Mitchell EA;Chaffey BT;McCaskie AW;Lakey JH;Birch MA
通讯作者：
Birch MA
DOI：
10.1002/advs.202100798
发表时间：
2021-10
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Dellaquila A;Le Bao C;Letourneur D;Simon-Yarza T
通讯作者：
Simon-Yarza T