Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis.
Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis.
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DOI：
10.1001/jamadermatol.2013.7954
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发表时间：
2014-03
期刊：
影响因子：
10.9
通讯作者：
Mitra, Nandita
中科院分区：
文献类型：
--
作者：
Margolis, David J.;Kim, Brian;Apter, Andrea J.;Gupta, Jayanta;Hoffstad, Ole;Papadopoulos, Maryte;Mitra, Nandita
特应性皮炎（AD）是儿童常见的慢性疾病。本研究的目的是评估胸腺基质淋巴细胞生成素（TSLP）变异与AD皮肤症状持续性之间的关系。前瞻性队列研究一般社区儿童入组儿科湿疹择期登记研究。TSLP变异的评价。主要结果和测量：自我报告的结果，即儿童的皮肤是否在6个月内以6个月的间隔无AD。我们评估了TSLP的14种变体。在白色受试者中，TSLP变体rs1898671与结果显著相关（p = 0.014）。通过重叠置信区间测量，在白人（1.72（1.11，2.65））和非洲裔美国人（1.34（0.51，3.51））中观察到相似的OR。此外，在FLG功能缺失突变个体的子队列中，TSLP变异个体更可能具有较低的持续性疾病（4.92（2.04，11.86））。关于AD的临床持久性，TSLP变异与较不持久的疾病相关。因此，TSLP可能是治疗AD的潜在治疗靶点，特别是在那些由于FLG突变而导致屏障功能降低的患者中。这是一个有吸引力的假设，可以在临床试验中进行测试。
Atopic dermatitis (AD) is a common chronic illness of childhood. The goal of this study was to evaluate the association between Thymic stromal lymphopoietin (TSLP) variation and the persistence of skin symptoms of AD. Prospective cohort study General community Children enrolled in the Pediatric Eczema Elective Registry. Evaluation of TSLP variation. Main outcomes and measures: Self-reported outcome of whether or not a child’s skin was AD symptom-free for 6-months at 6 month intervals. We evaluated 14 variants of TSLP. TSLP variant rs1898671 was significantly associated with the outcome in white subjects (p = 0.014). As measured by overlapping confidence intervals, similar ORs were noted among whites (1.72 (1.11, 2.65)) and African-American (1.34(0.51, 3.51)). Further within the subcohort of individuals with a FLG loss of function mutation, those with TSLP variation were more likely to have less persistent disease ((4.92 (2.04, 11.86)). With respect to the clinical persistence of AD, TSLP variation is associated with less persistent disease. Therefore, TSLP may be a potential therapeutic target for the treatment of AD, especially in those with diminished barrier function due to FLG mutations. This is an attractive hypothesis that can be tested in clinical trials.
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