Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190.
Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190.
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调节吗啡功能的非编码 RNA：重点关注 miR-190 的体内和体外功能
DOI：
10.3389/fgene.2012.00113
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发表时间：
2012
影响因子：
3.7
通讯作者：
Loh HH
中科院分区：
文献类型：
--
作者：
Zheng H;Law PY;Loh HH
据报道，非编码RNA(NcRNAs)，特别是microRNAs参与了多种生物过程，包括与药物成瘾有关的几个过程。阿片类药物是一种典型的成瘾药物，其生物学功能受ncRNAs调控。在目前的综述中，我们考察了ncRNAs调节μ阿片受体(OPRM1)活性从而促进阿片成瘾发展的各种机制。以miR-23b为例，我们提出了ncRNA介导的OPRM1表达调节可能影响阿片成瘾的方式。以miR-190为例，我们展示了ncRNAs在从受体到全身反应的信号级联中所发挥的关键作用，包括可能对成人神经发生和体内上下文记忆的调节。在讨论了ncRNAs参与阿片成瘾形成的可能靶点后，我们总结了ncRNAs与阿片成瘾相互作用的机制，并提出了进一步研究的建议。
Non-coding RNAs (ncRNAs), especially microRNAs, are reported to be involved in a variety of biological processes, including several processes related to drug addiction. It has been suggested that the biological functions of opioids, one typical type of addictive drugs, are regulated by ncRNAs. In the current review, we examine a variety of mechanisms through which ncRNAs could regulate μ-opioid receptor (OPRM1) activities and thereby contribute to the development of opioid addiction. Using miR-23b as an example, we present the possible ways in which ncRNA-mediated regulation of OPRM1 expression could impact opioid addiction. Using miR-190 as an example, we demonstrate the critical roles played by ncRNAs in the signal cascade from receptor to systemic responses, including the possible modulation of adult neurogenesis and in vivo contextual memory. After discussing the possible targets of ncRNAs involved in the development of opioid addiction, we summarize the mechanisms underlying the interaction between ncRNAs and opioid addiction and present suggestions for further study.
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影响因子：
4.8
作者：
Chu J;Zheng H;Zhang Y;Loh HH;Law PY
通讯作者：
Law PY
影响因子：
16.2
作者：
Edbauer, Dieter;Neilson, Joel R.;Foster, Kelly A.;Wang, Chi-Fong;Seeburg, Daniel P.;Batterton, Matthew N.;Tada, Tomoko;Dolan, Bridget M.;Sharp, Phillip A.;Sheng, Morgan
通讯作者：
Sheng, Morgan
DOI：
10.1073/pnas.120552597
发表时间：
2000-06-20
影响因子：
11.1
作者：
Eisch, AJ;Barrot, M;Nestler, EJ
通讯作者：
Nestler, EJ
影响因子：
3.8
作者：
BRODSKY, M;ELLIOTT, K;INTURRISI, CE
通讯作者：
INTURRISI, CE
影响因子：
3.7
作者：
Caputo V;Sinibaldi L;Fiorentino A;Parisi C;Catalanotto C;Pasini A;Cogoni C;Pizzuti A
通讯作者：
Pizzuti A