Muscarinic agonists modulate spontaneous and evoked unit discharge in auditory cortex of cat
Muscarinic agonists modulate spontaneous and evoked unit discharge in auditory cortex of cat
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毒蕈碱激动剂调节猫听觉皮层的自发和诱发单位放电
DOI：
10.1002/syn.890020109
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发表时间：
1988
期刊：
影响因子：
2.3
通讯作者：
N. Weinberger
中科院分区：
文献类型：
--
作者：
T. McKenna;J. Ashe;Gabriel K. Hui;N. Weinberger
本实验研究了胆碱能激动剂和拮抗剂对听皮层神经元自发放电和声诱发放电的影响，并检查这些影响是否由毒蕈碱胆碱能受体介导。本报告的主要重点是分析这些药物对自发和音调诱发放电以及诱发放电的不同时间成分的特定影响。单神经元记录在听觉皮层的长期准备，清醒的猫与多管微管电极。声刺激的反应之前，期间，和之后连续喷射胆碱能激动剂或拮抗剂的微压。定量分析神经元自发放电的平均放电率和对应于音调“开”、“通”和“关”反应的音调诱发PSTH的不同峰值。乙酰胆碱（ACh）和乙酰-β-乙酰甲胆碱（MCh）分别对72%和68%的测试神经元的自发活动产生显著影响。分别有92%和82%的测试细胞受到音调诱发反应的影响。这些激动剂改变自发或诱发活动的能力具有剂量依赖性。激动剂对自发活动和诱发活动的影响往往是不同的，在同一个细胞，然而，对自发活动的影响预测的“通过”的反应。ACh或MCh对诱发活动的最常见的影响是促进音调“开”反应。对于具有多成分放电模式的神经元，激动剂对不同的反应成分有不均匀的影响。然而，ACh对“开”和“关”反应的影响是共变的。因此，胆碱能激动剂对听皮层神经元反应的不同成分产生异质性的选择性作用，而不是简单地增加或减少放电水平。在阿托品存在下，胆碱能激动剂的作用被改变。MCh的作用被阿托品阻断的比例高于ACh。
The present experiments studied the effects of cholinergic agonists and antagonists on the spontaneous and acoustic‐evoked discharge of auditory cortical neurons and examined whether these effects were mediated by muscarinic cholinergic receptors. A primary focus of this report is the analysis of specific effects of these agents on the spontaneous and tone‐evoked discharge and on different temporal components of the evoked discharge. Single neurons were recorded in the auditory cortex of chronically prepared, awake cats with multibarrel micropipette electrodes. The responses to acoustic stimuli were obtained before, during, and following continuous ejection of cholinergic agonist or antagonists by micropressure. The mean rate of discharge of the neurons was analyzed quantitatively for spontaneous discharge and for different peaks of the tone‐evoked PSTH corresponding to tone “on,” “through,” and “off” responses. Acetylcholine (ACh) and acetyl‐β‐methacholine (MCh) produced significant effects on spontaneous activity in 72% and 68% of neurons tested, respectively. Tone‐evoked responses were effected in 92% and 82% of cells tested, respectively. The ability of these agonists to modify spontaneous or evoked activity was dose‐dependent. Agonist effects on spontaneous and evoked activity were often different in the same cell; however, effects on spontaneous activity did predict effects on “through” responses. The most common effect of ACh or MCh on evoked activity was facilitation of the tone “on” responses. For neurons with multicomponent discharge patterns in response to tones, the agonists had nonuniform effects on different response components. However, the effects of ACh on the “on” and “off” responses covaried. Hence cholinergic agonists produce heterogenous, selective effects on different components of the responses of auditory cortical neurons rather than simple increases or decreases in discharge level. The effects of cholinergic agonists were modified in the presence of atropine. The effects of MCh were blocked by atropine in a higher proportion of cases than those of ACh.
大鼠皮质事件相关慢电位的产生涉及基底核胆碱能神经支配。
DOI：
10.1016/0013-4694(86)90128-8
发表时间：
1986
期刊：
Electroencephalography and clinical neurophysiology
影响因子：
--
作者：
Pirch,JH;Corbus,MJ;Rigdon,GC;Lyness,WH
通讯作者：
Lyness,WH
[3h]pirenzepine 选择性识别大鼠大脑皮层中毒蕈碱胆碱能受体的高亲和力群体。
影响因子：
6.1
作者：
Watson,M;Roeske,WR;Yamamura,HI
通讯作者：
Yamamura,HI