Fetal Gender of the First Born and the Recurrent Risk of Spontaneous Preterm Birth
Fetal Gender of the First Born and the Recurrent Risk of Spontaneous Preterm Birth
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首胎胎儿性别和自然早产复发风险
DOI：
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发表时间：
2015
影响因子：
2
通讯作者：
A. Ravelli
中科院分区：
文献类型：
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作者：
E. Kamphuis;Bouchra Koullali;M. Hof;C. D. de Groot;B. Kazemier;S. Robertson;B. Mol;A. Ravelli
摘要目的探讨首次妊娠自发性早产（sPTB）妇女，首次妊娠胎儿性别对sPTB复发风险的影响。 研究设计：一项全国范围的回顾性队列研究（数据来自国家围产期登记处），研究对象为1999-2009年连续两次单胎妊娠的所有女性，首次分娩终止于sPTB <37周。 我们使用逻辑回归分析来研究第一次怀孕的胎儿性别与复发性sPTB风险之间的关系。我们重复了sPTB < 32周的分析。结果343853例首次妊娠≤ 37周sPTB的发生率为4.5%（15,351/343,853）。 在这15，351名女性中，与第一胎为男性相比，第一胎为女性时复发性sPTB <37周的风险增加（15.8% vs. 15.2%;校正比值比[aOR] 1.2; 95%置信区间[CI] 1.05-1.3）。对于sPTB <32周观察到类似的效果（8.2 vs. 5.9%; aOR 4.5; 95% CI 1.5-13）。结论与男性胎儿sPTB患者相比，女性胎儿sPTB患者复发sPTB的风险增加。 这些信息为sPTB是由独立的母体和胎儿因素引起的假设提供了证据。
Abstract Objective To study, in women with a spontaneous preterm birth (sPTB) in the first pregnancy, the effect of fetal sex in that first pregnancy on the recurrent sPTB risk. Study Design A nationwide retrospective cohort study (data from National Perinatal Registry) on all women with two sequential singleton pregnancies (1999–2009) with the first delivery ending in sPTB <37 weeks. We used logistic regression analysis to study the association between fetal gender in the first pregnancy and the risk of recurrent sPTB. We repeated the analysis for sPTB < 32 weeks. Results The overall incidence of sPTB <37 weeks in the first pregnancy was 4.5% (15,351/343,853). Among those 15,351 women, the risk of recurrent sPTB <37 weeks was increased when the first fetus was female compared when that fetus was male (15.8 vs. 15.2%; adjusted odds ratio [aOR] 1.2; 95% confidence interval [CI] 1.05–1.3). A similar effect was seen for sPTB <32weeks (8.2 vs. 5.9%; aOR 4.5; 95% CI 1.5–13). Conclusion Women who suffer sPTB of a female fetus have an increased risk of recurrent sPTB compared with women who suffer sPTB of a male fetus. This information provides proof for the hypothesis that sPTB is due to an independent maternal and fetal factor.
影响因子：
120.7
作者：
Crump, Casey;Sundquist, Kristina;Winkleby, Marilyn A.
通讯作者：
Winkleby, Marilyn A.
影响因子：
4
作者：
Schober, Linda;Radnai, Diana;Steinborn, Andrea
通讯作者：
Steinborn, Andrea