Peripherally injected scopolamine differentially modulates acetylcholine release in vivo in the young and aged rats
Peripherally injected scopolamine differentially modulates acetylcholine release in vivo in the young and aged rats
复制标题
外周注射东莨菪碱差异调节年轻和老年大鼠体内乙酰胆碱的释放
DOI：
10.1016/0304-3940(95)11914-i
复制
发表时间：
1995
影响因子：
2.5
通讯作者：
F. Casamenti
中科院分区：
文献类型：
--
作者：
C. Scali;M. Vannucchi;G. Pepeu;F. Casamenti
采用横向微渗析的方法，观察了在3月龄和24月龄自由活动大鼠的大脑皮层、海马区和纹状体区，腹腔注射东莨菪碱(1 mg/kg)对乙酰胆碱(ACh)释放的影响。在顶叶皮质，给药后老年大鼠ACh释放的增加明显大于青年大鼠，老年大鼠和青年大鼠的ACh释放量最大分别增加约600%和300%。在海马区，年轻组(+900%)比老年组(+600%)的ACh释放量增加更多。老年大鼠纹状体内注射东莨菪碱后40min才增加40%，而幼年大鼠纹状体内这种增加至少持续2小时，最高可达100%左右。这些发现表明，体内ACh释放的调节在大脑皮层中的影响方式与在海马体和纹状体中不同。
The effect of intraperitoneal administration of scopolamine (1 mg/kg) on acetylcholine (ACh) release in vivo in 3- and 24-month-old freely behaving rats was investigated in the cerebral cortex, hippocampus and striatum by means of transverse microdialysis. In the parietal cortex, the increase in ACh release after scopolamine administration was significantly greater in the old than in the young rats, reaching a maximum increase of about 600 and 300% in the old and young animals, respectively. In the hippocampus, scopolamine caused a larger increase in ACh release in the young (+900%) than in the old rats (+600%). In the striatum of aged rats, a 40% increase occurred only at 40 min after scopolamine administration while in the striatum of young animals the increase lasted for at least 2 h, reaching a maximum of about 100%. These findings demonstrate that the modulation of ACh release in vivo is affected in a different manner in the cerebral cortex than in the hippocampus and striatum by aging.
影响因子：
56.9
作者：
GIBSON, GE;PETERSON, C;JENDEN, DJ
通讯作者：
JENDEN, DJ
影响因子：
56.9
作者：
MASH, DC;FLYNN, DD;POTTER, LT
通讯作者：
POTTER, LT