Revisiting Key Entry Routes of Human Epidemic Arboviruses into the Mainland Americas through Large-Scale Phylogenomics.
Revisiting Key Entry Routes of Human Epidemic Arboviruses into the Mainland Americas through Large-Scale Phylogenomics.
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DOI：
10.1155/2018/6941735
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发表时间：
2018
影响因子：
2.9
通讯作者：
Pena LJ
中科院分区：
文献类型：
--
作者：
Campos TL;Durães-Carvalho R;Rezende AM;de Carvalho OV;Kohl A;Wallau GL;Pena LJ
基孔肯雅病毒（CHIKV）、登革热（DENV）和寨卡病毒（ZIKV）在全球范围内的快速传播引起了国际社会的极大关注。关于这些虫媒病毒进入美洲大陆的途径和地理扩张的知识仍然不完整和有争议。虫媒病毒引起的流行病继续在全球造成社会经济负担，特别是在因气候或基础设施因素难以控制病媒的国家。了解病毒如何从一个国家传播到另一个国家，对于帮助政府和卫生官员预测未来的流行病以及采取措施帮助控制或减轻病毒的传播至关重要。通过分析随时间推移在不同地点收集的虫媒病毒基因组序列，我们确定了累积突变的模式，能够追踪这些病毒的传播途径。在这里，我们应用强大的基因组学方法来追踪这些虫媒病毒的进化动态，特别关注巴西，这些三重流行病的震中。我们的研究结果表明，CHIKV，DENV-1-4和ZIKV在首次引入美洲大陆之前遵循了类似的路径，强调了在国家之间人口流动的主要入境点（如机场和海港）进行系统性虫媒病毒监测的必要性。
The rapid worldwide spread of chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV) viruses have raised great international concern. Knowledge about the entry routes and geographic expansion of these arboviruses to the mainland Americas remain incomplete and controversial. Epidemics caused by arboviruses continue to cause socioeconomic burden globally, particularly in countries where vector control is difficult due to climatic or infrastructure factors. Understanding how the virus circulates and moves from one country to another is of paramount importance to assist government and health officials in anticipating future epidemics, as well as to take steps to help control or mitigate the spread of the virus. Through the analyses of the sequences of arbovirus genomes collected at different locations over time, we identified patterns of accumulated mutations, being able to trace routes of dispersion of these viruses. Here, we applied robust phylogenomic methods to trace the evolutionary dynamics of these arboviruses with special focus on Brazil, the epicenter of these triple epidemics. Our results show that CHIKV, DENV-1–4, and ZIKV followed a similar path prior to their first introductions into the mainland Americas, underscoring the need for systematic arboviral surveillance at major entry points of human population movement between countries such as airports and seaports.
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DOI：
10.1126/science.aaf5036
发表时间：
2016-04-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Faria NR;Azevedo RDSDS;Kraemer MUG;Souza R;Cunha MS;Hill SC;Thézé J;Bonsall MB;Bowden TA;Rissanen I;Rocco IM;Nogueira JS;Maeda AY;Vasami FGDS;Macedo FLL;Suzuki A;Rodrigues SG;Cruz ACR;Nunes BT;Medeiros DBA;Rodrigues DSG;Queiroz ALN;da Silva EVP;Henriques DF;da Rosa EST;de Oliveira CS;Martins LC;Vasconcelos HB;Casseb LMN;Simith DB;Messina JP;Abade L;Lourenço J;Alcantara LCJ;de Lima MM;Giovanetti M;Hay SI;de Oliveira RS;Lemos PDS;de Oliveira LF;de Lima CPS;da Silva SP;de Vasconcelos JM;Franco L;Cardoso JF;Vianez-Júnior JLDSG;Mir D;Bello G;Delatorre E;Khan K;Creatore M;Coelho GE;de Oliveira WK;Tesh R;Pybus OG;Nunes MRT;Vasconcelos PFC
通讯作者：
Vasconcelos PFC
影响因子：
3.8
作者：
de Melo FL;Romano CM;de Andrade Zanotto PM
通讯作者：
de Andrade Zanotto PM
影响因子：
6.5
作者：
Anisimova, Maria;Gascuel, Olivier
通讯作者：
Gascuel, Olivier
DOI：
10.4269/ajtmh.2012.11-0770
发表时间：
2012-10-01
影响因子：
3.3
作者：
Dick, Olivia Brathwaite;San Martin, Jose L.;Dayan, Gustavo H.
通讯作者：
Dayan, Gustavo H.
影响因子：
5.4
作者：
Carrington, CVF;Foster, JE;Holmes, EC
通讯作者：
Holmes, EC