Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis.
Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis.
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DOI：
10.1016/j.pbi.2022.102189
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发表时间：
2022-04
影响因子：
9.5
通讯作者：
Peters RJ
中科院分区：
文献类型：
--
作者：
Wang Z;Peters RJ
丹参酮是传统中药丹参（Salvia miltiorrhiza）的生物活性二萜类成分，并且是广泛存在于唇形科植物家族中的酚性松香烷的实例。由于对这些与劳丹相关的二萜类天然产物的极大兴趣，它们的生物合成已被深入研究。除了为代谢工程的努力提供基础之外，这项工作还对唇形科中与劳丹相关的二萜类化合物生物合成产生了更广泛的开创性见解。这包括芳构化的立体化学预示，在相关的二萜合酶，以及相关酶的更广泛的系统发育保守的新的蛋白质结构域的损失。除了更广泛的代谢的这种总结之外，最近还阐明了丹参酮特征的呋喃环的形成。然而，生物催化剂对去甲基化仍然未知，这些反应的进一步芳构化观察到的丹参酮的有趣的潜在联系推测在这里。
Tanshinones are the bioactive diterpenoid constituents of the traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza), and are examples of the phenolic abietanes widely found within the Lamiaceae plant family. Due to the significant interest in these labdane-related diterpenoid natural products, their biosynthesis has been intensively investigated. In addition to providing the basis for metabolic engineering efforts, this work further yielded pioneering insights into labdane-related diterpenoid biosynthesis in the Lamiaceae more broadly. This includes stereochemical foreshadowing of aromatization, with novel protein domain loss in the relevant diterpene synthase, as well as broader phylogenetic conservation of the relevant enzymes. Beyond such summary of more widespread metabolism, formation of the furan ring that characterizes the tanshinones also has been recently elucidated. Nevertheless, the biocatalysts for the pair of demethylations remain unknown, and the intriguing potential connection of these reactions to the further aromatization observed in the tanshinones are speculated upon here.
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DOI：
10.1002/anie.201510650
发表时间：
2016-02-05
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Andersen-Ranberg J;Kongstad KT;Nielsen MT;Jensen NB;Pateraki I;Bach SS;Hamberger B;Zerbe P;Staerk D;Bohlmann J;Møller BL;Hamberger B
通讯作者：
Hamberger B
影响因子：
2.7
作者：
Cheng, Qiqing;Su, Ping;Huang, Luqi
通讯作者：
Huang, Luqi
DOI：
10.1073/pnas.1523787113
发表时间：
2016-03-29
影响因子：
11.1
作者：
Ignea, Codruta;Athanasakoglou, Anastasia;Kampranis, Sotirios C.
通讯作者：
Kampranis, Sotirios C.
影响因子：
11.9
作者：
Gao Y;Honzatko RB;Peters RJ
通讯作者：
Peters RJ
影响因子：
5.2
作者：
Gao W;Hillwig ML;Huang L;Cui G;Wang X;Kong J;Yang B;Peters RJ
通讯作者：
Peters RJ