Association between serum homocysteine and arterial stiffness in elderly: a community-based study.
Association between serum homocysteine and arterial stiffness in elderly: a community-based study.
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老年人血清同型半胱氨酸与动脉僵硬度之间的关联：一项基于社区的研究
DOI：
10.3969/j.issn.1671-5411.2014.01.007
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Ye P
中科院分区：
文献类型：
--
作者：
Zhang S;Bai YY;Luo LM;Xiao WK;Wu HM;Ye P
背景动脉硬化和同型半胱氨酸都是心血管疾病的强有力的预测因子，尤其是在老年人群中。以前的研究已经调查了人类受试者中同型半胱氨酸与动脉僵硬度的关系，而同型半胱氨酸与老年人动脉僵硬度之间的关系仍然不确定。本研究探讨了中国社区老年人同型半胱氨酸与动脉硬化的关系。方法我们将来自中国北京两个社区的780名参与者（46.3%男性，平均年龄71.9岁（范围65-96岁））的血清同型半胱氨酸水平与两种动脉硬度指标（颈动脉-股动脉脉搏波速度（PWV）和颈动脉-桡动脉PWV）相关联。在生物标志物测量的两天内测量动脉硬度。结果在多重校正模型中，即使校正了心血管疾病的经典危险因素，同型半胱氨酸水平仍与颈-股动脉PWV密切相关（标准化β = 0.13，P < 0.001）。当颈动脉-股动脉PWV高于正常值时，这种关联也更强，而颈动脉-桡动脉PWV与同型半胱氨酸无显著关联。结论中国老年人血清同型半胱氨酸水平与主动脉僵硬度的改变有关。
Background Arterial stiffness and homocysteine are both powerful predictors of cardiovascular disease, especially in older populations. Previous studies have investigated the association of homocysteine with arterial stiffness in human subjects, while the relationship between homocysteine and arterial stiffness in the elderly is still indefinite. The current study examined the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. Methods We related serum levels of homocysteine to two measures of arterial stiffness (carotid-femoral pulse wave velocity (PWV) and carotid-radial PWV) in 780 participants (46.3% men, mean age 71.9 years (ranging 65–96 years old)) from two communities of Beijing, China. Arterial stiffness was measured within two days of the time of biomarker measurement. Results In multiple-adjusted models, homocysteine levels were strongly associated with the carotid-femoral PWV (standardized β = 0.13, P < 0.001), even after adjustment for classical risk factors of cardiovascular disease. The association is also stronger when the carotid-femoral PWV is elevated above normal, whereas no significant association with homocysteine was observed for carotid-radial PWV. Conclusions In Chinese elderly persons, serum homocysteine levels are associated with alterations of aortic stiffness.
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影响因子：
4.9
作者：
van Dijk, Suzanne C.;Smulders, Yvo M.;van der Velde, Nathalie
通讯作者：
van der Velde, Nathalie
影响因子：
3.6
作者：
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通讯作者：
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影响因子：
6.1
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通讯作者：
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