Multiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation.
Multiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation.
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阿拉伯骆驼肾脏的多组学分析揭示了胆固醇在水资源保护中的作用。
DOI：
10.1038/s42003-021-02327-3
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发表时间：
2021-06-23
影响因子：
5.9
通讯作者：
Greenwood MP
中科院分区：
文献类型：
--
作者：
Alvira-Iraizoz F;Gillard BT;Lin P;Paterson A;Pauža AG;Ali MA;Alabsi AH;Burger PA;Hamadi N;Adem A;Murphy D;Greenwood MP
阿拉伯骆驼（Camelus dromedarius）是干旱和半干旱地区最重要的牲畜，为数百万人提供基本必需品。在当前气候变化的背景下，人们对骆驼在干旱条件下生存的机制重新产生了兴趣。最近的研究描述了揭示进化适应沙漠环境的基因组特征。我们现在提出了单峰肾的转录组和蛋白质组的综合目录，并描述了基因表达是如何作为慢性脱水和急性补液的结果而被调节的。我们的分析表明胆固醇生物合成过程的富集和与离子运输相关的类别的过度代表。因此，我们进一步验证了受胆固醇水平变化影响的差异表达基因在水资源保护中的已知作用。我们的数据表明，抑制胆固醇生物合成可能通过间接促进aqp2介导的水重吸收来促进肾脏中的水潴持。Fernando Alvira-Iraizoz和Benjamin T. Gillard等人全面编目了单峰骆驼对慢性脱水应激和随后的急性补液反应的肾脏转录组和蛋白质组。他们的研究结果表明，抑制胆固醇的生物合成可能促进单峰骆驼肾脏中的水分保留，从而进一步了解这些动物如何在干旱条件下生存。
The Arabian camel (Camelus dromedarius) is the most important livestock animal in arid and semi-arid regions and provides basic necessities to millions of people. In the current context of climate change, there is renewed interest in the mechanisms that enable camelids to survive in arid conditions. Recent investigations described genomic signatures revealing evolutionary adaptations to desert environments. We now present a comprehensive catalogue of the transcriptomes and proteomes of the dromedary kidney and describe how gene expression is modulated as a consequence of chronic dehydration and acute rehydration. Our analyses suggested an enrichment of the cholesterol biosynthetic process and an overrepresentation of categories related to ion transport. Thus, we further validated differentially expressed genes with known roles in water conservation which are affected by changes in cholesterol levels. Our datasets suggest that suppression of cholesterol biosynthesis may facilitate water retention in the kidney by indirectly facilitating the AQP2-mediated water reabsorption. Fernando Alvira-Iraizoz and Benjamin T. Gillard et al. comprehensively catalogue the kidney transcriptome and proteome of dromedary camels in response to chronic dehydration stress and subsequent acute rehydration. Their results suggest that the suppression of the cholesterol biosynthesis may facilitate water retention in the dromedary camel kidney, providing further insight into how these animals survive in arid conditions.
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影响因子：
5.9
作者：
BERLINER, RW;BENNETT, CM
通讯作者：
BENNETT, CM
影响因子：
2.6
作者：
Ali MA;Abu Damir H;Ali OM;Amir N;Tariq S;Greenwood MP;Lin P;Gillard B;Murphy D;Adem A
通讯作者：
Adem A
DOI：
10.1073/pnas.1519508113
发表时间：
2016-06-14
影响因子：
11.1
作者：
Almathen, Faisal;Charruau, Pauline;Burger, Pamela A.
通讯作者：
Burger, Pamela A.
影响因子：
4.5
作者：
Boone, Michelle;Deen, Peter M. T.
通讯作者：
Deen, Peter M. T.
影响因子：
1.7
作者：
Al-Atiyat, Raed Mahmoud;Suliman, Gamal;Basmaeil, Saeid
通讯作者：
Basmaeil, Saeid