The Dynamics of Infectious Diseases Associated With Injection Drug Use in Lawrence and Lowell, Massachusetts.
The Dynamics of Infectious Diseases Associated With Injection Drug Use in Lawrence and Lowell, Massachusetts.
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在劳伦斯和洛厄尔，麻萨诸塞州与注射药物使用相关的传染病动态。
DOI：
10.1093/ofid/ofab128
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发表时间：
2021-06
影响因子：
4.2
通讯作者：
Warren JL
中科院分区：
文献类型：
--
作者：
Gonsalves GS;David Paltiel A;Thornhill T;Iloglu S;DeMaria A Jr;Cranston K;Monina Klevens R;Walensky RP;Warren JL
注射吸毒有多种感染性并发症。了解这些并发症的轨迹可能有助于开发针对注射吸毒者 (PWID) 中经常发生的人类免疫缺陷病毒 (HIV) 爆发的早期预警系统。使用贝叶斯环境中的分布式滞后泊松回归模型来检查 2005 年至 2018 年间马萨诸塞州劳伦斯和洛厄尔注射相关传染病发病率的时间模式及其与 HIV 病例的关联。当月 HIV 计数与大约 8 个月前的致命过量用药、10 个月前的感染性心内膜炎病例以及 12 个月前与这些感染相关的皮肤和软组织感染以及切开引流手术病例相关。公共卫生部门收集与注射吸毒相关的其他并发症的数据可能很重要，因为这些并发症可以作为哨兵系统的输入，以触发早期干预并避免潜在的艾滋病毒爆发。
There are a wide variety of infectious complications of injection drug use. Understanding the trajectory of these complications might inform the development of an early warning system for human immunodeficiency virus (HIV) outbreaks that occur regularly among people who inject drugs (PWID). A distributed lag Poisson regression model in the Bayesian setting was used to examine temporal patterns in the incidence of injection-associated infectious diseases and their association with HIV cases in Lawrence and Lowell, Massachusetts between 2005 and 2018. Current-month HIV counts are associated with fatal overdoses approximately 8 months prior, cases of infective endocarditis 10 months prior, and cases of skin and soft tissue infections and incision and drainage procedures associated with these infections 12 months prior. Collecting data on these other complications associated with injection drug use by public health departments may be important to consider because these complications may serve as input to a sentinel system to trigger early intervention and avert potential outbreaks of HIV.
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