40 Years of RAS-A Historic Overview.
40 Years of RAS-A Historic Overview.
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DOI：
10.3390/genes12050681
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发表时间：
2021-05-01
期刊：
影响因子：
3.5
通讯作者：
Santos E
中科院分区：
文献类型：
--
作者：
Fernández-Medarde A;De Las Rivas J;Santos E
自第一个人类癌基因 (HRAS) 分离以来已有四十多年了，这是癌症研究的一个重要里程碑，通过 20 世纪 80 年代初几个选定的研究小组的共同努力成为可能。这些最初的发现使我们对癌症生物学的理解发生了质的飞跃，并开启了分子肿瘤学领域的开端。接下来的四十年的 RAS 研究产生了大量关于 RAS 小 GTP 酶家族的新知识，包括它们如何调节控制许多细胞生理过程的信号通路，或致癌突变如何触发病理状况，包括发育综合征或许多癌症类型。然而，尽管已有广泛的基础知识，但仍然缺乏针对 RAS 驱动的癌症的具体有效治疗方法。希望最近在 RAS 表面发现新型口袋以及能够阻断其与效应子和/或激活子相互作用的高度特异性小分子抑制剂的进展可能会导致新的、有效的癌症治疗方法的开发。这篇综述旨在对 RAS 研究的主要里程碑提供快速、总结的历史概述，从最初在啮齿类动物肿瘤中发现病毒 RAS 癌基因，到在各种人类癌症中针对 RAS 癌基因的最新尝试。
It has been over forty years since the isolation of the first human oncogene (HRAS), a crucial milestone in cancer research made possible through the combined efforts of a few selected research groups at the beginning of the 1980s. Those initial discoveries led to a quantitative leap in our understanding of cancer biology and set up the onset of the field of molecular oncology. The following four decades of RAS research have produced a huge pool of new knowledge about the RAS family of small GTPases, including how they regulate signaling pathways controlling many cellular physiological processes, or how oncogenic mutations trigger pathological conditions, including developmental syndromes or many cancer types. However, despite the extensive body of available basic knowledge, specific effective treatments for RAS-driven cancers are still lacking. Hopefully, recent advances involving the discovery of novel pockets on the RAS surface as well as highly specific small-molecule inhibitors able to block its interaction with effectors and/or activators may lead to the development of new, effective treatments for cancer. This review intends to provide a quick, summarized historical overview of the main milestones in RAS research spanning from the initial discovery of the viral RAS oncogenes in rodent tumors to the latest attempts at targeting RAS oncogenes in various human cancers.
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影响因子：
5.3
作者：
Agudo-Ibanez, Lorena;Herrero, Ana;Crespo, Piero
通讯作者：
Crespo, Piero
DOI：
10.1073/pnas.87.12.4849
发表时间：
1990-06-01
影响因子：
11.1
作者：
BRUNGER, AT;MILBURN, MV;KIM, SH
通讯作者：
KIM, SH
影响因子：
56.9
作者：
BENITO, M;PORRAS, A;SANTOS, E
通讯作者：
SANTOS, E
影响因子：
6.6
作者：
Batista, Wagner L.;Ogata, Fernando T.;Monteiro, Hugo P.
通讯作者：
Monteiro, Hugo P.
影响因子：
64.8
作者：
BURGERING, BMT;COFFER, PJ
通讯作者：
COFFER, PJ