Ethanol exposure increases total protein kinase C activity in human lymphocytes.

Ethanol exposure increases total protein kinase C activity in human lymphocytes.
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接触乙醇会增加人淋巴细胞中的总蛋白激酶 C 活性。

DOI:
10.1111/j.1530-0277.1993.tb00774.x
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发表时间:
1993
期刊:
Alcoholism, clinical and experimental research
影响因子:
--
通讯作者:
C. Liou
C. Liou
中科院分区:
--
文献类型:
--
作者:
P. DePetrillo;C. Liou

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分离人循环淋巴细胞并与乙醇孵育。测定胞浆、膜结合和总去污剂可提取蛋白激酶C(PKC)活性。暴露于乙醇(100 mm)导致PKC活性增加,与膜相关的PKC活性增加相对于胞质活性在5分钟的曝光。高达200 mM的较高浓度的乙醇与总去污剂可提取的PKC活性增加相关。乙醇是最有效的一系列的直链醇研究其对洗涤剂可提取的PKC活性的影响。
Human circulating lymphocytes were isolated and incubated with ethanol. Cytosolic, membrane-bound and total detergent extractable protein kinase C (PKC) activities were measured. Exposure to ethanol (100 mm) resulted in an increase in PKC activity, with membrane-associated PKC activity increasing with respect to cytosolic activity at 5 min of exposure. Higher concentrations of ethanol up to 200 mm were associated with increases in total detergent extractable PKC activity. Ethanol was the most potent of a series of straight chain alcohols studied for their effects on detergent-extractable PKC activity.
乙醇通过激活磷酸肌醇特异性磷脂酶 C 来刺激人血小板的形状变化。
DOI: 10.1016/0003-9861(88)90472-9
发表时间: 1988
影响因子: 3.9
作者:
Rubin,R;Ponnappa,BC;Thomas,AP;Hoek,JB
通讯作者: Hoek,JB
醇类激活腺苷酸环化酶需要核苷酸结合蛋白。
DOI: --
发表时间: 1984
期刊: The Journal of pharmacology and experimental therapeutics
影响因子: --
作者:
Luthin,GR;Tabakoff,B
通讯作者: Tabakoff,B
乙醇和二油精刺激星形胶质细胞中的 PKC 易位。
DOI: 10.1016/0024-3205(90)90476-8
发表时间: 1990
期刊: Life sciences
影响因子: 6.1
作者:
Skwish,S;Shain,W
通讯作者: Shain,W