Oral cortisol impairs implicit sequence learning
Oral cortisol impairs implicit sequence learning
复制标题
口服皮质醇损害内隐序列学习
DOI：
10.1007/s00213-010-2112-4
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发表时间：
2011
影响因子：
3.4
通讯作者：
H. Schächinger
中科院分区：
文献类型：
--
作者：
Sonja Römer;A. Schulz;Steffen Richter;J. Lass;H. Schächinger
肾上腺皮质激素已被证明可以影响陈述性记忆，这是一种由内侧颞叶结构操作的对事实和事件的明确记忆形式。最近的神经影像学数据表明，内侧颞叶（包括海马体）在内隐序列学习中也很活跃。目的探讨糖皮质激素是否也会影响内隐序列学习。方法29例健康受试者口服皮质醇（30 mg）， 31例对照组给予安慰剂。治疗一小时后，所有志愿者通过按下相同颜色的按钮来对不同颜色的灯做出反应，完成了五个连续的反应时间任务。受试者在不知情的情况下对一个准随机的刺激序列做出反应，包括高阶顺序规律（两种颜色的组合，预测下一个目标颜色）。确定每个按钮按下的反应速度（每块100次），并计算差异分数作为学习的证明。结果两组学生在整个实验过程中均表现出显著的内隐序列学习。然而，我们发现与安慰剂组相比，皮质醇组的学习表现受损。进一步的分析表明，皮质醇组的学习延迟发生在任务的一开始。结论本研究首次发现外源性应激激素皮质醇导致内隐记忆功能受损。这种影响可能取决于海马体参与内隐序列学习，但也讨论了其他大脑结构的参与。
RationaleGlucocorticoids have been shown to affect declarative memory, an explicit form of memory for facts and events operated by medial temporal lobe structures. Recent neuroimaging data suggest that the medial temporal lobe (including the hippocampus) is also active in implicit sequence learning.ObjectivesThe aim of the present study was to investigate whether implicit sequence learning may also be affected by glucocorticoid administration.MethodsOral cortisol (30 mg) was given to 29 healthy subjects whereas 31 control subjects received placebo. One hour after treatment all volunteers performed five consecutive blocks of a five-choice serial reaction time task by responding to colored lights by pressing buttons of the same color. The subjects responded without knowing to a quasi-randomized stimulus sequence, including higher-order sequential regularities (a combination of two colors that predicted the following target color). The reaction speed of every button-press (100 per block) was determined and difference scores were calculated as a proof of learning.ResultsBoth groups showed significant implicit sequence learning throughout the experiment. However, we found an impaired learning performance of the cortisol group compared with the placebo group. Further analysis revealed that a delayed learning in the cortisol group occurred at the very beginning of the task.ConclusionsThis study is the first human investigation indicating impaired implicit memory function after exogenous administration of the stress hormone cortisol. This effect may depend on hippocampus engagement in implicit sequence learning, but the involvement of other brain structures is also discussed.
影响因子：
--
作者：
Newcomer, JW;Selke, G;Alderson, AL
通讯作者：
Alderson, AL