A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation.
A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation.
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DOI：
10.1126/science.1177087
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发表时间：
2009-10-23
期刊：
影响因子：
--
通讯作者：
Bonni A
中科院分区：
文献类型：
--
作者：
Yang Y;Kim AH;Yamada T;Wu B;Bilimoria PM;Ikeuchi Y;de la Iglesia N;Shen J;Bonni A
Presynaptic axonal differentiation is essential for synapse formation and the establishment of neuronal circuits. However, the mechanisms that coordinate presynaptic development in the brain are largely unknown. Here, we found the major mitotic E3 ubiquitin ligase Cdc20-anaphase promoting complex (Cdc20-APC) regulates presynaptic differentiation in primary postmitotic mammalian neurons and in the rat cerebellar cortex. Cdc20-APC triggered the degradation of the transcription factor NeuroD2, and thereby promoted presynaptic differentiation. The NeuroD2 target gene Complexin II, which acts locally at presynaptic sites, mediated the ability of NeuroD2 to suppress presynaptic differentiation. Thus, our findings define a Cdc20-APC ubiquitin signaling pathway that governs presynaptic development, which holds important implications for neuronal connectivity and plasticity in the brain.
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