Habitual physical activity and peripheral arterial compliance in young adults: the Amsterdam growth and health longitudinal study.
Habitual physical activity and peripheral arterial compliance in young adults: the Amsterdam growth and health longitudinal study.
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年轻人的习惯性身体活动和外周动脉顺应性：阿姆斯特丹生长和健康纵向研究。
DOI：
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发表时间：
2011
影响因子：
3.2
通讯作者：
C. Stehouwer
中科院分区：
文献类型：
--
作者：
R. J. van de Laar;Isabel Ferreira;W. van Mechelen;M. Prins;J. Twisk;C. Stehouwer
背景
目前尚不清楚习惯性体力活动（HPA）对中枢动脉僵硬度与外周动脉僵硬度的影响是否不同，两者都对心血管健康有害。我们研究了不同强度的HPA对年轻人肱动脉和股动脉僵硬度的影响，并将其与先前在同一研究人群中获得的颈动脉僵硬度进行了比较。
方法
对373名受试者的HPAs和其他生活方式和生物学变量进行了前瞻性测量数据（13至36岁之间的8次重复测量），这些受试者在36岁时评估了肱动脉和股动脉以及颈动脉的僵硬度。广义估计方程用于检查肱动脉和股动脉扩张性（DC）和顺应性（CC）系数的性别特异性三分位数之间在HPA（分钟/周）中花费的时间差异。
结果
在调整潜在混杂因素后，36岁时肱动脉和股动脉CC最高（顺应性更高）与最低三分位数（顺应性更低）的受试者在整个纵向期间平均花费更多时间进行剧烈运动（分别为+21.2（95%CI：2.0; 40.4）和+24.4（5.0; 43.8）），但不是轻中度HPA。这些差异分别有28%和62%是由强HPA相关的对其他心血管危险因素的有利影响解释的。然而，在肱动脉和股动脉DC中没有观察到这种相关性。
结论
终生精力旺盛，但不是轻至中度，HPA与肱动脉和股动脉顺应性有利相关，但与DC无关。总而言之，这些和我们以前的研究结果，因此建议广义的活力HPA相关的适应，虽然不同的性质，在整个动脉树。
BACKGROUND
It remains unclear whether the impact of habitual physical activity (HPA) differs for central vs. peripheral arterial stiffness, both of which are detrimental to cardiovascular health. We investigated the associations of lifetime HPA of different intensities on brachial and femoral stiffness in young adults, and compared these with those previously obtained for the carotid artery in the same study population.
METHODS
Prospectively measured data (eight repeated measures between ages 13 and 36 years) on HPAs, and other lifestyle and biological variables, were retrieved for 373 subjects in whom stiffness of the brachial and femoral, as well as the carotid, arteries was assessed at age 36 years. Generalized estimating equations were used to examine the differences in time spent in HPAs (min/week) across sex-specific tertiles of the brachial and femoral distensibility (DC) and compliance (CC) coefficients.
RESULTS
After adjustment for potential confounders, subjects in the highest (more compliant) vs. those in the lowest tertiles of the brachial and femoral CCs (less compliant) at age 36 years had spent on average more time in vigorous (+21.2 (95%CI:2.0; 40.4) and +24.4 (5.0; 43.8), respectively) but not in light-to-moderate HPAs throughout the longitudinal period. These differences were explained by 28 and 62%, respectively, by vigorous-HPA-related favorable impacts on other cardiovascular risk factors. No such associations were observed for the brachial and femoral DCs, however.
CONCLUSIONS
Lifetime vigorous, but not light-to-moderate, HPA is favorably associated with brachial and femoral compliance, but not DC. Altogether, these and our previous findings thus suggest generalized vigorous-HPA-related adaptations, although of different nature, throughout the arterial tree.
影响因子：
3.2
作者：
Chase, Nancy L.;Sui, Xuemei;Blair, Steven N.
通讯作者：
Blair, Steven N.
DOI：
10.1016/s0735-1097(01)01348-1
发表时间：
2001-08-01
影响因子：
24
作者：
Seals, DR;Tanaka, H;DeSouza, CA
通讯作者：
DeSouza, CA