Interventions Increase Vaccination Rates in Inflammatory Bowel Disease and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.
Interventions Increase Vaccination Rates in Inflammatory Bowel Disease and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.
复制标题
DOI：
10.1007/s10620-023-07903-7
复制
发表时间：
2023-07
影响因子：
3.1
通讯作者：
Piper, Marc S. S.
中科院分区：
文献类型：
--
作者：
Patel, Jalpa;Noureldin, Mohamed;Fakhouri, Dina;Farraye, Francis A. A.;Kovar-Gough, Iris;Warren, Bradley;Waljee, Akbar K. K.;Piper, Marc S. S.
患有炎症性肠病（IBD）和类风湿关节炎（RA）等免疫介导疾病的患者有发生疫苗可预防感染的风险。尽管有指南建议，但先前的研究显示疫苗接种率并不理想。
我们进行了一项系统综述和荟萃分析，以比较旨在提高疫苗接种率的不同干预措施。
我们对截至2020年的MEDLINE/PubMed、Embase、CINAHL和Cochrane图书馆进行了系统检索，以查找旨在提高疫苗接种率的干预措施相关研究。我们进行了一项随机效应荟萃分析，以生成合并优势比（OR），从而评估所有干预措施与无干预措施的情况。我们的主要结局是肺炎球菌疫苗（PCV）接种率。
我们的综述发现了8580篇文章，其中15篇关于IBD和8篇关于RA的文章符合纳入标准；21篇文章被纳入分析。PCV是主要的疫苗（91%）。在我们对IBD患者的分析中，与无干预相比，几乎所有干预措施（以患者为导向、以医生为导向或以障碍为导向）都提高了PCV的接种率[优势比为4.74；95%置信区间为2.44 - 6.56，I² = 90%]。在以障碍为导向的研究中效果最为显著[优势比为12.68；95%置信区间为2.21 - 72.62，I² = 92%]。对于RA的数据，与无干预相比，所有干预措施都提高了PCV的接种率（优势比2.74；95%置信区间为1.80 - 4.17，I² = 95%）。
我们的数据表明，许多不同的干预措施都可以提高PCV接种率。似乎以障碍为导向的干预措施对提高PCV接种率可能具有最大的积极影响。然而，应该鼓励临床医生实施最适合其临床实践的措施。未来需要高质量的随机对照试验来确定优化疫苗接种率的最佳方法。
网络版包含补充材料，可在10.1007/s10620 - 023 - 07903 - 7获取。
Patients with immune-mediated conditions such as IBD and RA are at risk for vaccine-preventable infections. Despite guideline recommendations, prior studies have shown suboptimal vaccination rates. We conducted a systematic review and meta-analysis to compare the different interventions intended to increase vaccination rates. A systematic search was conducted of MEDLINE/PubMed, Embase, CINAHL, and Cochrane Library up to 2020 for studies with interventions intended to increase vaccination rates. We performed a random-effects meta-analysis to generate pooled odds ratios (ORs) to assess all interventions against no interventions. Our primary outcome was pneumococcal vaccination (PCV) rate. Our review found 8580 articles, for which 15 IBD and 8 RA articles met the inclusion criteria; 21 articles were included in the analysis. PCV was the predominant vaccination (91%). In our analysis of patients with IBD, almost all interventions (patient-oriented, physician-oriented, or barrier-oriented) increased PCV uptake [OR, 4.74; 95% CI, 2.44–6.56, I2 = 90%] compared to no intervention. The greatest effect was seen in barrier-oriented studies [OR, 12.68; 95% CI, 2.21–72.62, I2 = 92%]. For RA data, all interventions had increased PCV uptake compared to no interventions (OR 2.74; 95% CI, 1.80–4.17, I2 = 95%). Our data suggest that many different interventions can increase PCV rates. It appears that barrier-oriented interventions may have the greatest positive effect on increasing PCV uptake. However, clinicians should be encouraged to implement measures best suited to their practice. Future high-quality randomized controlled trials are needed to determine the best approach to optimize vaccination rates. The online version contains supplementary material available at 10.1007/s10620-023-07903-7.
登录
查看更多内容
DOI：
10.1016/0749-5978(91)90020-t
发表时间：
1991-12-01
影响因子：
4.6
作者：
AJZEN, I
通讯作者：
AJZEN, I
影响因子：
3.9
作者：
Aguirre, Alfredo;Trupin, Laura;Yazdany, Jinoos
通讯作者：
Yazdany, Jinoos
影响因子：
14.6
作者：
Ioannidis, John P. A.;Trikalinos, Thomas A.
通讯作者：
Trikalinos, Thomas A.
影响因子：
3.9
作者：
Broderick, Rachel;Ventura, Iazsmin;Giles, Jon T.
通讯作者：
Giles, Jon T.
影响因子：
7.6
作者：
Long, M. D.;Martin, C.;Kappelman, M. D.
通讯作者：
Kappelman, M. D.