A new therapeutic approach to dialysis amyloidosis: intensive removal of beta 2-microglobulin with adsorbent column.
A new therapeutic approach to dialysis amyloidosis: intensive removal of beta 2-microglobulin with adsorbent column.
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透析淀粉样变性的新治疗方法：用吸附柱强化去除β2-微球蛋白。
DOI：
10.1111/j.1525-1594.1993.tb00574.x
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发表时间：
2008
影响因子：
2.4
通讯作者：
M. Arakawa
中科院分区：
文献类型：
--
作者：
F. Gejyo;N. Homma;S. Hasegawa;M. Arakawa
淀粉样变性是一种长期血液透析的常见和严重并发症，其中淀粉样蛋白由β2微球蛋白(β2 M)组成。其发展机制尚不完全清楚。由于β2-M是一种淀粉样蛋白，因此尽可能多地去除它是至关重要的。开发了一种用于直接血液灌流的β2-M的特异性吸附剂。该吸附剂是疏水性有机化合物共价结合在其上的多孔性纤维素小球。高通量膜透析器和吸附柱(BM-01)的组合将使有效地清除β2-M成为可能。采用直接血液灌流(DHP)和吸附柱相结合的透析可消除超过200-300毫克的β2-M。我们观察了5例患者，用该柱(BM-01)联合高通量透析治疗1周(3例)、6个月(1例)、14个月(1例)，每周3次。结果表明，BM-01吸附柱能有效地去除血液中的β2-M，且无严重不良反应。因此，它有可能抑制透析性淀粉样变性的进展。结合使用这种吸附柱(BM-01)和高通量透析器，可以提供一种从体内去除β2-M的改进方法。
Amyloidosis, in which amyloid protein consists of beta 2-microglobulin (beta 2-M), is both a common and a serious complication of long-term hemodialysis. The mechanism of its development is not completely understood. Since beta 2-M is an amyloid protein, it is essential to try to remove as much of it as possible. A specific adsorbent of beta 2-M has been developed for use in direct hemoperfusion. The adsorbent is a porous cellulose bead to which hydrophobic organic compound is bound covalently. A combination of a high-flux membrane dialyzer and an adsorption column (BM-01) would make it possible to efficiently eliminate beta 2-M. Dialysis with a combination of direct hemoperfusion (DHP) and an adsorption column led to the elimination of more than 200-300 mg of beta 2-M. We observed 5 patients who received treatment with this column (BM-01) in combination with high-flux dialysis 3 times a week for periods of 1 week (3 patients), 6 months (1 patient), or 14 months (1 patient). It is demonstrated that the adsorbent column (BM-01) provides an intensive method to eliminate beta 2-M from the blood with no serious adverse effect. It thus has the potential to suppress the progression of dialysis amyloidosis. The use of this adsorbent column (BM-01) in combination with a high-flux dialyzer may present an improved approach to removing beta 2-M from the body.
DOI：
10.1016/0006-291x(85)91948-5
发表时间：
1985-01-01
影响因子：
3.1
作者：
GEJYO, F;YAMADA, T;SCHMID, K
通讯作者：
SCHMID, K