Sex Differences In Avoidance Extinction After Contextual Fear Conditioning: Anxioescapic Behavior In Female Rats.
Sex Differences In Avoidance Extinction After Contextual Fear Conditioning: Anxioescapic Behavior In Female Rats.
复制标题
DOI：
10.1016/j.neuroscience.2022.06.031
复制
发表时间：
2022-08-10
期刊：
影响因子：
3.3
通讯作者：
Vazdarjanova, Almira I.
中科院分区：
文献类型：
--
作者：
Shanazz, Khadijah;Dixon-Melvin, Rachael;Nalloor, Rebecca;Thumar, Riya;Vazdarjanova, Almira I.
恐惧记忆对生存很重要，并且与恐惧障碍的病因有关，例如创伤后应激障碍（PTSD）。恐惧记忆在临床前已经得到了很好的研究，啮齿动物恐惧表达的性别差异也有报道：雌性动物比雄性动物更容易冻结。这是否是恐惧学习或表达的差异还存在争议。我们的目标是通过一项任务来区分这些可能性，该任务允许雌性大鼠通过移动而不是冻结来表达恐惧记忆。我们评估了雌性和雄性大鼠在Y迷宫的隔离电击臂中进行情境恐惧条件反射后的恐惧消退，方法是将它们放回隔离电击臂中（电击情境中的恐惧消退）或在消退训练期间允许它们在Y迷宫中自由移动并进入/避开电击臂（回避消退）。我们证实，在这两种情况下，雌性大鼠在恐惧消退期间比雄性大鼠冻结得少。然而，在回避灭绝期间，两性对休克情境的回避相似，表现出相当的恐惧记忆和灭绝。此外，雌性大鼠更多地进入非电击臂。因此，雌性和雄性大鼠具有相似的恐惧学习，但雌性大鼠用主动运动反应表达恐惧。此外，雌性大鼠在其他致焦虑条件（高架加迷宫）下也表现出主动运动反应，并具有较高的反应性（声惊吓反应），但在存在引发恐惧的刺激物（猫毛和足电击）时则没有。总之，雌性大鼠对焦虑刺激有一种主动的运动反应，我们称之为“逃避性”行为策略。
Fear memories are important for survival and are implicated in the etiology of fear disorders such as Post Traumatic Stress Disorder (PTSD). Fear memories are well studied pre-clinically and sex differences in rodent fear expression have been reported: females tend to freeze less than males. Whether this is a difference in fear learning or expression is debated. We aimed to differentiate between these possibilities with a task that allowed female rats to express fear memory by moving, rather than freezing. We assessed fear extinction after contextual fear conditioning in the isolated Shock Arm of a Y-maze in female and male rats by either placing them back in the isolated Shock Arm (Fear Extinction in the Shock Context) or allowing them to move freely in the Y-maze during extinction training and enter/avoid the Shock Arm (Avoidance Extinction). We confirmed that female rats freeze less than males during fear extinction in both settings. During Avoidance Extinction, however, both sexes had similar avoidance of the Shock Context, showing comparable fear memory and extinction. Additionally, female rats made more entries into the non-shock arms. Thus, female and male rats have similar fear learning but females express it with an active motor response. Furthermore, female rats also exhibited an active motor response under other anxiogenic conditions (Elevated Plus Maze) and had higher reactivity (Acoustic Startle Response) but not when fear-eliciting stimuli were present: cat hair and foot-shock. In summary, female rats have an active motor response to anxiogenic stimuli which we termed ‘Anxioescapic’ behavior strategy.
登录
查看更多内容
影响因子：
3.5
作者：
Frye, CA;Walf, AA
通讯作者：
Walf, AA
影响因子：
7.7
作者：
Gruene, Tina M.;Flick, Katelyn;Shansky, Rebecca M.
通讯作者：
Shansky, Rebecca M.
DOI：
10.3758/bf03211975
发表时间：
1976-01-01
期刊：
ANIMAL LEARNING & BEHAVIOR
影响因子：
--
作者：
BOLLES, RC;COLLIER, AC
通讯作者：
COLLIER, AC
影响因子：
3.6
作者：
Hogg, S
通讯作者：
Hogg, S
DOI：
10.1037/h0027676
发表时间：
1969-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BLANCHAR.RJ;BLANCHAR.DC
通讯作者：
BLANCHAR.DC