The microRNA-17 ~ 92 Family as a Key Regulator of Neurogenesis and Potential Regenerative Therapeutics of Neurological Disorders.
The microRNA-17 ~ 92 Family as a Key Regulator of Neurogenesis and Potential Regenerative Therapeutics of Neurological Disorders.
复制标题
与 92 家族类似的 microRNA-17 作为神经发生的关键调节因子和神经系统疾病的潜在再生治疗
DOI：
10.1007/s12015-020-10050-5
复制
发表时间：
2022-03
影响因子：
4.8
通讯作者：
Zheng JC
中科院分区：
文献类型：
--
作者：
Xia X;Wang Y;Zheng JC
miR-17 ~ 92, an miRNA family containing three paralogous polycistronic clusters, was initially considered as an oncogene and was later demonstrated to trigger various physiological and pathological processes. Emerging evidence has implicated miR-17 ~ 92 family as a master regulator of neurogenesis. Through targeting numerous genes that affect cell cycle arrest, stemness deprivation, and lineage commitment, miR-17 ~ 92 family controls the proliferation and neuronal differentiation of neural stem/progenitor cells in both developmental and adult brains. Due to the essential roles of miR-17 ~ 92 family, its misexpression is widely associated with acute and chronic neurological disorders by attenuating neurogenesis and facilitating neuronal apoptosis. The promising neurogenic potential of miR-17 ~ 92 family also makes it a promising “medicine” to activate the endogenous and exogenous regenerative machinery, thus enhance tissue repair and function recovery after brain injury. In this review, we focus on the recent progress made toward understanding the involvement of miR-17 ~ 92 family in regulating both developmental and adult neurogenesis, and discuss the regenerative potential of miR-17 ~ 92 family in treating neurological disorders. Graphical abstract
登录
查看更多内容
影响因子：
8.8
作者：
Bian S;Hong J;Li Q;Schebelle L;Pollock A;Knauss JL;Garg V;Sun T
通讯作者：
Sun T
影响因子：
3.4
作者：
Chen Y;Bian S;Zhang J;Zhang H;Tang B;Sun T
通讯作者：
Sun T
影响因子：
8
作者：
Ernst, A.;Campos, B.;Radlwimmer, B.
通讯作者：
Radlwimmer, B.
miR-19b-3p通过Plzf整合Jak-Stat信号通路调节奶山羊雄性种系干细胞的自我更新
DOI：
10.1016/j.biocel.2018.10.010
发表时间：
2018-12-01
影响因子：
4
作者：
Clotaire, Daguia Zambe John;Du, Xiaomin;Hua, Jinlian
通讯作者：
Hua, Jinlian
影响因子：
2.5
作者：
Chaves, Juliana C. S.;Machado, Felippe T.;Ferrari, Merari F. R.
通讯作者：
Ferrari, Merari F. R.