Large ventral lateral neurons modulate arousal and sleep in Drosophila.
Large ventral lateral neurons modulate arousal and sleep in Drosophila.
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DOI：
10.1016/j.cub.2008.08.033
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发表时间：
2008-10-28
期刊：
影响因子：
9.2
通讯作者：
Holmes, Todd C.
中科院分区：
文献类型：
--
作者：
Sheeba, Vasu;Fogle, Keri J.;Kaneko, Maki;Rashid, Saima;Chou, Yu-Ting;Sharma, Vijay K.;Holmes, Todd C.
Large ventral lateral clock neurons (lLNv) exhibit higher daytime light-driven spontaneous action potential firing rates in Drosophila, coinciding with wakefulness and locomotor activity behaviour. To determine whether the lLNv are involved in arousal and sleep/wake behaviour we examined the effects of altered electrical excitation of the LNv. LNv-hyperexcited flies reverse the normal day/night firing pattern, showing higher lLNv firing rates at night and pigment dispersing factor-mediated enhancement of nocturnal locomotor activity behaviour and reduced quantity and quality of sleep. lLNv hyperexcitation impairs sensory arousal, as shown by physiological and behavioural assays. lLNv hyperexcited flies lacking sLNv neurons exhibit robust hyperexcitation-induced increases in nocturnal behaviour, suggesting that the sLNv are not essential for mediation of arousal. Light-activated lLNv neurons modulate behavioural arousal and sleep in Drosophila.
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影响因子：
64.5
作者：
Nitabach, MN;Blau, J;Holmes, TC
通讯作者：
Holmes, TC
DOI：
10.1007/s003590050192
发表时间：
1998-04-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
影响因子：
--
作者：
Helfrich-Förster, C
通讯作者：
Helfrich-Förster, C
影响因子：
64.8
作者：
Grima, B;Chèlot, E;Rouyer, F
通讯作者：
Rouyer, F
影响因子：
5.3
作者：
Luan, HJ;Lemon, WC;White, BH
通讯作者：
White, BH
DOI：
10.1002/neu.20053
发表时间：
2005-01-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Nitabach, MN;Sheeba, V;Holmes, TC
通讯作者：
Holmes, TC