Knowledge-based IMRT planning for individual liver cancer patients using a novel specific model.
Knowledge-based IMRT planning for individual liver cancer patients using a novel specific model.
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使用新型特定模型为个体肝癌患者制定基于知识的 IMRT 计划
DOI：
10.1186/s13014-018-0996-z
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发表时间：
2018-03-27
期刊：
影响因子：
--
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Yu G;Li Y;Feng Z;Tao C;Yu Z;Li B;Li D
本研究的目的是将RapidPlan与具有特殊解剖特征的患者肝脏调强放疗（IMRT）治疗的临床方案进行比较，并研究一般模型（model - g）与我们的特定模型（model - s）的预测能力。方法采用RapidPlan知识计划系统，以60例肝癌患者为研究对象，建立2个模型（Model-S、Model-G）。模型- s由30例具有特殊解剖特征的患者组成，这些患者从计划靶体积（PTV）到右肾的距离小于3厘米，模型- g采用该库中所有60例患者进行配置。对13例患者组成的评估组，采用与Model-S相似的Model-G、Model-S和手动(M)制定基于知识的IMRT计划，分别命名为RPG-plans、RPS-plans和M-plans。比较rp -计划与相应的m -计划、rpg -计划与rps -计划剂量-体积直方图（DVHs）的差异。结果对13例患者，RapidPlan均能自动生成临床可接受的方案。rp计划与m计划相比，rp计划改善了95%的PTV，并且在右肾有更大的剂量节约。对于正常肝脏，rpg计划提供相似的剂量，而rps计划提供比m计划更高的剂量。与RapidPlan模型相比，rps计划具有更好的符合指数（CI）值，对右肾的剂量较低，对脊髓的点剂量最大，而对正常肝脏的剂量较高。结论研究表明，RapidPlan可以创建高质量的计划，我们的特定模型可以提高PTV的CI，从而使肝癌患者在IMRT中更多地节省OAR。
BackgroundThe purpose of this work is to benchmark RapidPlan against clinical plans for liver Intensity-modulated radiotherapy (IMRT) treatment of patients with special anatomical characteristics, and to investigate the prediction capability of the general model (Model-G) versus our specific model (Model-S).MethodsA library consisting of 60 liver cancer patients with IMRT planning was used to set up two models (Model-S, Model-G), using the RapidPlan knowledge-based planning system. Model-S consisted of 30 patients with special anatomical characteristics where the distance from planning target volume (PTV) to the right kidney was less than three centimeters and Model-G was configurated using all 60 patients in this library. Knowledge-based IMRT plans were created for the evaluation group formed of 13 patients similar to those included in Model-S by Model-G, Model-S and manually (M), named RPG-plans, RPS-plans and M-plans, respectively. The differences in the dose-volume histograms (DVHs) were compared, not only between RP-plans and their respective M-plans, but also between RPG-plans and RPS-plans.ResultsFor all 13 patients, RapidPlan could automatically produce clinically acceptable plans. Comparing RP-plans to M-plans, RP-plans improved V95%of PTV and had greater dose sparing in the right kidney. For the normal liver, RPG-plans delivered similar doses, while RPS-plans delivered a higher dose than M-plans. With respect to RapidPlan models, RPS-plans had better conformity index (CI) values and delivered lower doses to the right kidney V20Gyand maximizing point doses to spinal cord, while delivering higher doses to the normal liver.ConclusionThe study shows that RapidPlan can create high-quality plans, and our specific model can improve the CI of PTV, resulting in more sparing of OAR in IMRT for individual liver cancer patients.
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影响因子：
3.8
作者：
Zhu, Xiaofeng;Ge, Yaorong;Wu, Q. Jackie
通讯作者：
Wu, Q. Jackie
DOI：
10.1016/j.ijrobp.2012.04.015
发表时间：
2013-03-01
影响因子：
7
作者：
Voet, Peter W. J.;Dirkx, Maarten L. P.;Heijmen, Ben J. M.
通讯作者：
Heijmen, Ben J. M.
影响因子：
3.5
作者：
Djajaputra, D;Wu, QW;Mohan, R
通讯作者：
Mohan, R
DOI：
10.1016/j.ijrobp.2010.05.026
发表时间：
2011-03-15
影响因子：
7
作者：
Wu, Binbin;Ricchetti, Francesco;McNutt, Todd
通讯作者：
McNutt, Todd
影响因子：
3.8
作者：
Wu, Binbin;Ricchetti, Francesco;McNutt, Todd
通讯作者：
McNutt, Todd