Inflammation triggered by the NLRP3 inflammasome is a critical driver of diabetic bladder dysfunction.
Inflammation triggered by the NLRP3 inflammasome is a critical driver of diabetic bladder dysfunction.
复制标题
由NLRP3炎性体触发的炎症是糖尿病膀胱功能障碍的关键驱动因素。
DOI：
10.3389/fphys.2022.920487
复制
发表时间：
2022
影响因子：
4
通讯作者：
Purves, J. Todd
中科院分区：
文献类型：
--
作者：
Hughes Jr, Francis M. M.;Odom, Michael R. R.;Cervantes, Anissa;Purves, J. Todd
糖尿病是一种迅速蔓延的流行病，预计到2050年将影响多达三分之一的美国人。这种疾病的特点是破坏性的并发症所带来的高血糖和代谢紊乱。这些并发症中最常见的是糖尿病膀胱功能障碍（DBD），估计有50-80%的患者患有这种疾病。不幸的是，糖尿病干预和并发症流行病学研究表明，严格的血糖控制并不能降低尿失禁的风险，尽管它确实降低了其他并发症的风险，如视网膜病变，肾病和神经病变。因此，更好地了解DBD以开发靶向疗法来减轻患者痛苦的需求显著未得到满足。最近，研究界已经了解到，糖尿病会产生一种称为元炎症的低水平炎症的全身状态，并且注意力集中在称为NLRP 3炎性体的无菌炎症诱导结构的作用上。在这篇综述中，我们将研究NLRP 3在诱导DBD和驱动其向活性不足表型发展中起核心作用的证据。
Diabetes is a rapidly expanding epidemic projected to affect as many as 1 in 3 Americans by 2050. This disease is characterized by devastating complications brought about high glucose and metabolic derangement. The most common of these complications is diabetic bladder dysfunction (DBD) and estimates suggest that 50–80% of patients experience this disorder. Unfortunately, the Epidemiology of Diabetes Interventions and Complications Study suggests that strict glucose control does not decrease ones risk for incontinence, although it does decrease the risk of other complications such as retinopathy, nephropathy and neuropathy. Thus, there is a significant unmet need to better understand DBD in order to develop targeted therapies to alleviate patient suffering. Recently, the research community has come to understand that diabetes produces a systemic state of low-level inflammation known as meta-inflammation and attention has focused on a role for the sterile inflammation-inducing structure known as the NLRP3 inflammasome. In this review, we will examine the evidence that NLRP3 plays a central role in inducing DBD and driving its progression towards an underactive phenotype.
登录
查看更多内容
影响因子：
6.6
作者：
Daneshgari, Firouz;Liu, Guiming;Imrey, Peter B.
通讯作者：
Imrey, Peter B.
DOI：
10.1523/jneurosci.3795-08.2008
发表时间：
2008-12-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Binshtok AM;Wang H;Zimmermann K;Amaya F;Vardeh D;Shi L;Brenner GJ;Ji RR;Bean BP;Woolf CJ;Samad TA
通讯作者：
Samad TA
影响因子：
5.6
作者：
Baum P;Toyka KV;Blüher M;Kosacka J;Nowicki M
通讯作者：
Nowicki M
DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
作者：
Aglietti, Robin A.;Estevez, Alberto;Dueber, Erin C.
通讯作者：
Dueber, Erin C.
影响因子：
4.5
作者：
Christ, George J.;Hsieh, Yi;Melman, Arnold
通讯作者：
Melman, Arnold