Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.
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DOI：
10.1007/s11882-015-0581-6
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发表时间：
2016-01
影响因子：
5.5
通讯作者：
Doherty, Taylor A.
中科院分区：
文献类型：
--
作者：
Karta, Maya R.;Broide, David H.;Doherty, Taylor A.
最近的发现导致了一组新的免疫细胞，先天淋巴样细胞（ILCs）的鉴定。这一群体的成员被分为三个亚群：ILC1s、ILC2s和ILC3s。在被上皮细胞源性细胞因子、脂质介质（半胱氨酸白三烯和前列腺素D2）和TNF家族成员TL1A激活后，ILC2s产生Th2细胞因子、IL-4、IL-5和IL-13，并促进抗原暴露后气道的结构和免疫细胞反应。此外，ILC2的功能还受到诱导型T细胞共刺激剂(ICOS)/ ICOS-配体（ICOS- l）通过免疫细胞之间的直接接触相互作用的影响。最常见的气道抗原是过敏原和病毒，它们与诱导具有潜在2型炎症的气道疾病（包括哮喘和过敏性鼻炎）高度相关。基于最近发现的ILC2s与气道Th2反应之间的联系，人们对ILC2s在人类疾病中的作用进行了深入的研究，希望能更好地理解病理生理学和发现新的潜在治疗靶点。本文综述了近年来在阐明ILC2参与人类Th2气道疾病方面的进展。
Recent discoveries have led to the identification of a novel group of immune cells, the innate lymphoid cells (ILCs). The members of this group are divided into three subpopulations: ILC1s, ILC2s, and ILC3s. ILC2s produce Th2 cytokines, IL-4, IL-5, and IL-13, upon activation by epithelial cell-derived cytokines, lipid mediators (cysteinyl leukotrienes and prostaglandin D2), and TNF family member TL1A and promote structural and immune cell responses in the airways after antigen exposure. In addition, ILC2 function is also influenced by inducible T cell costimulator (ICOS)/ ICOS-ligand (ICOS-L) interactions via direct contact between immune cells. The most common airway antigens are allergens and viruses which are highly linked to the induction of airway diseases with underlying type 2 inflammation including asthma and allergic rhinitis. Based on recent findings linking ILC2s and airway Th2 responses, there is intensive investigation into the role of ILC2s in human disease with the hope of a better understanding of the pathophysiology and the discovery of novel potential therapeutic targets. This review summarizes the recent advances made in elucidating ILC2 involvement in human Th2 airway disease.
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DOI：
10.4049/jimmunol.1101632
发表时间：
2012-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Doherty TA;Khorram N;Sugimoto K;Sheppard D;Rosenthal P;Cho JY;Pham A;Miller M;Croft M;Broide DH
通讯作者：
Broide DH
影响因子：
32.4
作者：
Diefenbach, Andreas;Colonna, Marco;Koyasu, Shigeo
通讯作者：
Koyasu, Shigeo
影响因子：
14.2
作者：
Corrigan, Chris J.;Wang, Wei;Ying, Sun
通讯作者：
Ying, Sun
DOI：
10.1016/j.jaci.2014.11.037
发表时间：
2015-07
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Christianson CA;Goplen NP;Zafar I;Irvin C;Good JT Jr;Rollins DR;Gorentla B;Liu W;Gorska MM;Chu H;Martin RJ;Alam R
通讯作者：
Alam R
影响因子：
14.2
作者：
Fajt, Merritt L.;Gelhaus, Stacy L.;Freeman, Bruce;Uvalle, Crystal E.;Trudeau, John B.;Holguin, Fernando;Wenzel, Sally E.
通讯作者：
Wenzel, Sally E.