Aging is not equal across memory systems.
Aging is not equal across memory systems.
复制标题
在内存系统中，衰老不相等。
DOI：
10.1016/j.nlm.2020.107232
复制
发表时间：
2020-07
影响因子：
2.7
通讯作者：
Korol DL
中科院分区：
文献类型：
--
作者：
Gardner RS;Newman LA;Mohler EG;Tunur T;Gold PE;Korol DL
本实验比较了年龄对年轻（3-4个月）和老年（24-28个月）雄性Fischer-344大鼠学习几种海马和纹状体敏感任务的影响。在三组任务中，衰老不仅伴随着海马任务的缺陷，而且还伴随着纹状体任务能力的保持甚至增强。在两个新的物体识别任务，大鼠表现出受损的性能海马物体定位任务，但增强性能纹状体物体替换任务。在双重解决方案的任务，年轻的大鼠主要使用海马的解决方案和老年大鼠使用纹状体的解决方案。此外，在两个迷宫任务最佳解决使用无论是大脑皮层敏感的地方或纹状体敏感的反应策略，相对于年轻的大鼠，老年大鼠有受损的学习的地方版本，但同等的学习的响应版本。由于葡萄糖治疗可以逆转许多任务和环境中的学习和记忆缺陷，因此大脑中可用葡萄糖的水平可能对任务和记忆系统中观察到的认知老化具有特别重要的意义。在位置学习过程中，与年轻大鼠相比，老年大鼠海马中与训练相关的细胞外葡萄糖水平升高减弱。相比之下，在位置或反应任务训练的年轻和老年大鼠中，纹状体中的葡萄糖水平增加了10%。这些细胞外脑葡萄糖对训练的反应表明，随着大鼠年龄的增长，大脑皮层敏感性学习的障碍和纹状体敏感性学习的保留，这表明与年龄相关的学习变化和这些大脑区域的代谢底物可用性之间存在联系。
The present experiments compared the effects of aging on learning several hippocampus- and striatum-sensitive tasks in young (3–4 month) and old (24–28 month) male Fischer-344 rats. Across three sets of tasks, aging was accompanied not only by deficits on hippocampal tasks but also by maintained or even enhanced abilities on striatal tasks. On two novel object recognition tasks, rats showed impaired performance on a hippocampal object location task but enhanced performance on a striatal object replacement task. On a dual solution task, young rats predominately used hippocampal solutions and old rats used striatal solutions. In addition, on two maze tasks optimally solved using either hippocampus-sensitive place or striatum-sensitive response strategies, relative to young rats, old rats had impaired learning on the place version but equivalent learning on the response version. Because glucose treatments can reverse deficits in learning and memory across many tasks and contexts, levels of available glucose in the brain may have particular importance in cognitive aging observed across tasks and memory systems. During place learning, training-related rises in extracellular glucose levels were attenuated in the hippocampus of old rats compared to young rats. In contrast, glucose levels in the striatum increased comparably in young and old rats trained on either the place or response task. These extracellular brain glucose responses to training paralleled the impairment in hippocampus-sensitive learning and the sparing of striatum-sensitive learning seen as rats age, suggesting a link between age-related changes in learning and metabolic substrate availability in these brain regions.
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影响因子：
3.7
作者：
Bozzo L;Puyal J;Chatton JY
通讯作者：
Chatton JY
影响因子：
29
作者：
Díaz-García CM;Mongeon R;Lahmann C;Koveal D;Zucker H;Yellen G
通讯作者：
Yellen G
影响因子：
6.3
作者：
DiNuzzo, Mauro;Mangia, Silvia;Giove, Federico
通讯作者：
Giove, Federico
影响因子：
4.5
作者：
Bortolatto, Cristiani F.;Wilhelm, Ethel A.;Nogueira, Cristina W.
通讯作者：
Nogueira, Cristina W.
DOI：
10.1037/h0081022
发表时间：
1980-01-01
期刊：
CANADIAN JOURNAL OF PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE
影响因子：
--
作者：
BARNES, CA;NADEL, L;HONIG, WK
通讯作者：
HONIG, WK