Linking dopamine neurotransmission and neurogenesis: The evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster.
Linking dopamine neurotransmission and neurogenesis: The evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster.
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DOI：
10.1590/s1415-47572012000600004
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发表时间：
2012-12
影响因子：
2.1
通讯作者：
Bau CH
中科院分区：
文献类型：
--
作者：
Mota NR;Araujo-Jnr EV;Paixão-Côrtes VR;Bortolini MC;Bau CH
遗传学研究长期以来一直表明DRD 2基因在精神疾病和行为中的重要作用。进一步的研究表明，Chr 11 q22 -23区域的基因联合效应，包括NCAM 1，TTC 12，ANKK 1和DRD 2基因，或NCAM 1簇。尽管越来越需要解开这个集群的作用，很少有研究考虑到物种间和进化的方法。这项研究表明，行为相关的SNPs从若虫集群，如rs 1800497（Taq 1A）和rs6277，是古老的多态性，可以追溯到现代人和尼安德特人/丹尼索瓦人之间的共同祖先。保守的同线性和邻近性表明，若虫集群似乎已经建立了至少4亿年前，当第一个Sarcopians出现。NTAD基因显然受到共调节，这可能归因于适应性功能特性，包括当中枢神经系统变得更加复杂时出现的那些特性。最后，我们的研究结果表明，与神经发生和多巴胺能神经传递有关的Neptin基因，应该作为一个单位在行为和精神遗传学研究中进行探讨。
Genetic studies have long suggested the important role of the DRD2 gene in psychiatric disorders and behavior. Further research has shown a conjoined effect of genes in the Chr11q22–23 region, which includes the NCAM1, TTC12, ANKK1 and DRD2 genes, or NTAD cluster. Despite a growing need to unravel the role of this cluster, few studies have taken into account interspecies and evolutionary approaches. This study shows that behaviorally relevant SNPs from the NTAD cluster, such as rs1800497 (Taq1A) and rs6277, are ancient polymorphisms that date back to the common ancestor between modern humans and Neanderthals/Denisovans. Conserved synteny and neighborhood indicate the NTAD cluster seems to have been established at least 400 million years ago, when the first Sarcopterygians emerged. The NTAD genes are apparently co-regulated and this could be attributed to adaptive functional properties, including those that emerged when the central nervous system became more complex. Finally, our findings indicate that NTAD genes, which are related to neurogenesis and dopaminergic neurotransmission, should be approached as a unit in behavioral and psychiatric genetic studies.
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影响因子：
3
作者：
Castelo-Branco, Goncalo;Arenas, Ernest
通讯作者：
Arenas, Ernest
影响因子：
7
作者：
Kikuta, Hiroshi;Laplante, Mary;Becker, Thomas S.
通讯作者：
Becker, Thomas S.
影响因子：
7.6
作者：
Huang, Weihua;Payne, Thomas J.;Li, Ming D.
通讯作者：
Li, Ming D.
DOI：
10.1126/science.1188021
发表时间：
2010-05-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Green RE;Krause J;Briggs AW;Maricic T;Stenzel U;Kircher M;Patterson N;Li H;Zhai W;Fritz MH;Hansen NF;Durand EY;Malaspinas AS;Jensen JD;Marques-Bonet T;Alkan C;Prüfer K;Meyer M;Burbano HA;Good JM;Schultz R;Aximu-Petri A;Butthof A;Höber B;Höffner B;Siegemund M;Weihmann A;Nusbaum C;Lander ES;Russ C;Novod N;Affourtit J;Egholm M;Verna C;Rudan P;Brajkovic D;Kucan Ž;Gušic I;Doronichev VB;Golovanova LV;Lalueza-Fox C;de la Rasilla M;Fortea J;Rosas A;Schmitz RW;Johnson PLF;Eichler EE;Falush D;Birney E;Mullikin JC;Slatkin M;Nielsen R;Kelso J;Lachmann M;Reich D;Pääbo S
通讯作者：
Pääbo S
DOI：
10.1073/pnas.012464099
发表时间：
2002-01-08
影响因子：
11.1
作者：
Ding, YC;Chi, HC;Moyzis, RK
通讯作者：
Moyzis, RK