Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.
Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.
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DOI：
10.1038/s41467-023-40099-y
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发表时间：
2023-07-21
影响因子：
16.6
通讯作者：
Giovanetti, Marta
中科院分区：
文献类型：
--
作者：
Xavier, Joilson;Junior Alcantara, Luiz Carlos;Fonseca, Vagner;Lima, Mauricio;Castro, Emerson;Fritsch, Hegger;Oliveira, Carla;Guimaraes, Natalia;Adelino, Talita;Evaristo, Mariane;Rodrigues, Evandra S.;Santos, Elaine Vieira;de La-Roque, Debora;de Moraes, Laise;Tosta, Stephane;Neto, Adelino;Rosewell, Alexander;Mendonca, Ana Flavia;Leite, Anderson;Vasconcelos, Andreza;Silva de Mello, Arabela L.;Vasconcelos, Bergson;Montalbano, Camila A.;Zanluca, Camila;Freitas, Carla;de Albuquerque, Carlos F. C.;Duarte dos Santos, Claudia Nunes;Santos, Cleiton S.;dos Santos, Cliomar Alves;Maymone Goncalves, Crhistinne C.;Teixeira, Dalane;Neto, Daniel F. L.;Cabral, Diego;de Oliveira, Elaine C.;Noia Maciel, Ethel L.;Pereira, Felicidade Mota;Iani, Felipe;de Carvalho, Fernanda P.;Andrade, Gabriela;Bezerra, Gabriela;de Castro Lichs, Gislene G.;Pereira, Glauco Carvalho;Barroso, Haline;Ferreira Franz, Helena Cristina;Ferreira, Hivylla;Gomes, Iago;Riediger, Irina N.;Rodrigues, Isabela;de Siqueira, Isadora C.;Silva, Jacilane;Rico, Jairo Mendez;Lima, Jaqueline;Abrantes, Jayra;do Nascimento, Jean Phellipe M.;Wasserheit, Judith N.;Pastor, Julia;de Magalhes, Jurandy J. F.;Luz, Kleber Giovanni;Lima Neto, Lidio G.;Frutuoso, Livia C. V.;da Silva, Luana Barbosa;Sena, Ludmila;de Sousa, Luis Arthur F.;Pereira, Luiz Augusto;Demarchi, Luiz;Camara, Magaly C. B.;Astete, Marcela G.;Almiron, Maria;Lima, Maricelia;Umaki Zardin, Marina C. S.;Presibella, Mayra M.;Falco, Melissa B.;Gale, Michael, Jr.;Freire, Naishe;Marques, Nelson;de Moura, Noely F. O.;Almeida Da Silva, Pedro E.;Rabinowitz, Peter;da Cunha, Rivaldo V.;Trinta, Karen S.;do Carmo Said, Rodrigo F.;Kato, Rodrigo;Stabeli, Rodrigo;de Jesus, Ronaldo;Santos, Roselene Hans;Kashima, Simone;Slavov, Svetoslav N.;Andrade, Tamires;Rocha, Themis;Carneiro, Thiago;Nardy, Vanessa;da Silva, Vinicius;Carvalho, Walterlene G.;Van Voorhis, Wesley C.;Araujo, Wildo N.;de Filippis, Ana M. B.;Giovanetti, Marta
黄热病、寨卡病毒病、基孔肯雅热和登革热等蚊媒疾病在巴西的出现和再次出现对公共卫生产生了严重影响。自2014年在巴西东北部首次发现基孔肯雅病毒以来，该病毒在全国迅速传播，引发了人们的担忧。在这项工作中，我们与国家公共卫生实验室网络合作开展了基因组监测现场培训活动，在过去两年（2021 - 2022年）从巴西12个州生成了422个基孔肯雅病毒基因组，在此期间，该国报告的基孔肯雅热病例超过31.2万例。这些基因组增加了可用数据量，使我们能够更全面地描述基孔肯雅病毒东 - 中 - 南非谱系在巴西的传播动态。树形分支模式揭示了两个不同亚分支的出现和扩张。系统地理分析表明，东北地区一直是病毒向其他地区传播的主要中心。新基因组中C>T转换频率的增加表明，来自免疫系统的宿主限制因子，如ADAR和AID/APOBEC脱氨酶，可能推动了巴西基孔肯雅病毒的遗传多样性。
基孔肯雅病毒在巴西是地方性流行的，近年来病例迅速增加。在这里，作者描述了一个在全国范围内扩展的基因组监测项目，使他们能够描述主要源自东北地区的两个不同亚分支的出现和传播情况。
The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, and dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus across the country since its first detection in 2014 in Northeast Brazil. In this work, we carried out on-site training activities in genomic surveillance in partnership with the National Network of Public Health Laboratories that have led to the generation of 422 chikungunya virus genomes from 12 Brazilian states over the past two years (2021–2022), a period that has seen more than 312 thousand chikungunya fever cases reported in the country. These genomes increased the amount of available data and allowed a more comprehensive characterization of the dispersal dynamics of the chikungunya virus East-Central-South-African lineage in Brazil. Tree branching patterns revealed the emergence and expansion of two distinct subclades. Phylogeographic analysis indicated that the northeast region has been the leading hub of virus spread towards other regions. Increased frequency of C > T transitions among the new genomes suggested that host restriction factors from the immune system such as ADAR and AID/APOBEC deaminases might be driving the genetic diversity of the chikungunya virus in Brazil. Chikungunya virus is endemic in Brazil and cases have been rapidly increasing in recent years. Here, the authors describe the expansion of a genomic surveillance program across the country allowing them to characterise the emergence and dispersal of two distinct subclades mainly seeded from the north eastern region.
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影响因子：
11
作者：
Chaw, Shu-Miaw;Tai, Jui-Hung;Wang, Hurng-Yi
通讯作者：
Wang, Hurng-Yi
影响因子：
3.8
作者：
de Oliveira EC;Fonseca V;Xavier J;Adelino T;Morales Claro I;Fabri A;Marques Macario E;Viniski AE;Campos Souza CL;Gomes da Costa ES;Soares de Sousa C;Guimarães Dias Duarte F;Correia de Medeiros A;Campelo de Albuquerque CF;Venancio Cunha R;Oliveira De Moura NF;Bispo de Filippis AM;Oliveira T;Lourenço J;de Abreu AL;Alcantara LCJ;Giovanetti M
通讯作者：
Giovanetti M
影响因子：
81.5
作者：
Bartholomeeusen，Koen;Daniel，Matthieu;Arien，Kevin K.
通讯作者：
Arien，Kevin K.
影响因子：
3
作者：
Ciccolella, Simone;Denti, Luca;Bonizzoni, Paola;Della Vedova, Gianluca;Pirola, Yuri;Previtali, Marco
通讯作者：
Previtali, Marco
DOI：
10.3390/pathogens10070896
发表时间：
2021-07-15
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Costa ÉA;Giovanetti M;Silva Catenacci L;Fonseca V;Aburjaile FF;Chalhoub FLL;Xavier J;Campos de Melo Iani F;da Cunha E Silva Vieira MA;Freitas Henriques D;Medeiros DBA;Guedes MIMC;Senra Álvares da Silva Santos B;Gonçalves Silva AS;de Pino Albuquerque Maranhão R;da Costa Faria NR;Farinelli de Siqueira R;de Oliveira T;Ribeiro Leite Jardim Cavalcante K;Oliveira de Moura NF;Pecego Martins Romano A;Campelo de Albuquerque CF;Soares Feitosa LC;Martins Bayeux JJ;Bertoni Cavalcanti Teixeira R;Lisboa Lobato O;da Costa Silva S;Bispo de Filippis AM;Venâncio da Cunha R;Lourenço J;Alcantara LCJ
通讯作者：
Alcantara LCJ