B-lymphocyte lineage cells and the respiratory system.
B-lymphocyte lineage cells and the respiratory system.
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DOI：
10.1016/j.jaci.2013.02.023
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发表时间：
2013-04
影响因子：
14.2
通讯作者：
Schleimer, Robert P.
中科院分区：
文献类型：
--
作者：
Kato, Atsushi;Hulse, Kathryn E.;Tan, Bruce K.;Schleimer, Robert P.
呼吸道的适应性体液免疫反应是由B细胞和浆细胞介导的，它们表达高度进化的和特定的受体，并产生大多数同种类型的免疫球蛋白。在某些情况下，如自身免疫性疾病或因过度接触外来抗原而引起的炎症性疾病，这些相同的免疫细胞可以通过过度强烈的反应而致病。该综述讨论了B细胞和浆细胞的产生、分化、信号、激活和募集途径，特别强调了这些细胞亚群在呼吸系统中发挥作用的独特特征。在整个呼吸道产生负责效应器反应的B细胞的主要致敏事件通常发生在构成Waldeyer环的扁桃体和腺样体结构的上呼吸道。当二次暴露于呼吸道中的抗原时，处理抗原的树突状细胞迁移到次级淋巴器官，如引流上呼吸道和下呼吸道的淋巴结，在这些部位发生进一步的B细胞扩张。暴露在上呼吸道或下呼吸道的抗原也可以推动B系细胞在呼吸道粘膜组织中的扩张，并导致可诱导的淋巴滤泡或集合体的形成，从而介导局部免疫或疾病。
Adaptive humoral immune responses in the airways are mediated by B cells and plasma cells that express highly evolved and specific receptors and produce immunoglobulins of most isotypes. In some cases, such as autoimmune diseases or inflammatory diseases caused by excessive exposure to foreign antigens, these same immune cells can cause disease by virtue of overly vigorous responses. This review discusses the generation, differentiation, signaling, activation and recruitment pathways of B cells and plasma cells, with special emphasis on unique characteristics of subsets of these cells functioning within the respiratory system. The primary sensitization events that generate B cells responsible for effector responses throughout the airways usually occur in the upper airways, in tonsils and adenoid structures that make up Waldeyer’s Ring. Upon secondary exposure to antigen in the airways, antigen-processing dendritic cells migrate into secondary lymphoid organs such as lymph nodes that drain the upper and lower airways and further B cell expansion takes place at those sites. Antigen exposure in the upper or lower airways can also drive expansion of B lineage cells in the airway mucosal tissue and lead to the formation of inducible lymphoid follicles or aggregates that can mediate local immunity or disease.
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DOI：
10.1164/ajrccm/145.4_pt_1.911
发表时间：
1992-04-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
BOSKEN, CH;HARDS, J;HOGG, JC
通讯作者：
HOGG, JC
影响因子：
4.4
作者：
Avery, Danielle T.;Bryant, Vanessa L.;Tangye, Stuart G.
通讯作者：
Tangye, Stuart G.
DOI：
10.1165/ajrcmb.14.5.8624247
发表时间：
1996-05-01
影响因子：
6.4
作者：
Blyth, DI;Pedrick, MS;Fattah, D
通讯作者：
Fattah, D
影响因子：
6.1
作者：
Bilsborough, J.;Chadwick, E.;Dillon, S. R.
通讯作者：
Dillon, S. R.
影响因子：
5.8
作者：
Buckley, Rebecca H
通讯作者：
Buckley, Rebecca H