Social isolation and all-cause mortality: a population-based cohort study in Denmark.
Social isolation and all-cause mortality: a population-based cohort study in Denmark.
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DOI：
10.1038/s41598-018-22963-w
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发表时间：
2018-03-16
影响因子：
4.6
通讯作者：
Ehrenstein V
中科院分区：
文献类型：
--
作者：
Laugesen K;Baggesen LM;Schmidt SAJ;Glymour MM;Lasgaard M;Milstein A;Sørensen HT;Adler NE;Ehrenstein V
社会孤立与死亡率上升有关。然而，荟萃分析的结果表明效应量的异质性。我们的目的是通过进行一项基于人群的队列研究，为社会隔离和死亡率之间的关联提供新的证据。我们重新构建了伯克曼和赛姆的社会网络指数（SNI），该指数将社交网络的四个组成部分（伙伴关系，与家人/朋友的互动，宗教活动和组织/俱乐部的成员资格）合并为一个指数，范围从0/1（最社会孤立）到4（最不社会孤立）。我们估计了与SNI相关的累积死亡率和校正死亡率比（MRR）。我们调整了潜在的重要混杂因素，包括精神和躯体状态、生活方式和社会经济状况。SNI 0/1和SNI 4的男性7年累积死亡率分别为11%和5.4%，SNI 0/1和SNI 4的女性分别为9.6%和3.9%。比较SNI 0/1与SNI 4的校正MRR，男性为1.7（95% CI：1.1 - 2.6），女性为1.6（95% CI：0.83 - 2.9）。没有伴侣与男性调整后的MRR相关，男性为1.5（95%CI：1.2 - 2.1），女性为1.7（95%CI：1.2 - 2.4）。总之，社会隔离与60 - 70%的死亡率增加有关。没有伴侣与最高的MRR相关。
Social isolation is associated with increased mortality. Meta-analytic results, however, indicate heterogeneity in effect sizes. We aimed to provide new evidence to the association between social isolation and mortality by conducting a population-based cohort study. We reconstructed the Berkman and Syme’s social network index (SNI), which combines four components of social networks (partnership, interaction with family/friends, religious activities, and membership in organizations/clubs) into an index, ranging from 0/1 (most socially isolated) to 4 (least socially isolated). We estimated cumulative mortality and adjusted mortality rate ratios (MRR) associated with SNI. We adjusted for potential important confounders, including psychiatric and somatic status, lifestyle, and socioeconomic status. Cumulative 7-year mortality in men was 11% for SNI 0/1 and 5.4% for SNI 4 and in women 9.6% for SNI 0/1 and 3.9% for SNI 4. Adjusted MRRs comparing SNI 0/1 with SNI 4 were 1.7 (95% CI: 1.1–2.6) among men and 1.6 (95% CI: 0.83–2.9) among women. Having no partner was associated with an adjusted MRR of 1.5 (95% CI: 1.2–2.1) for men and 1.7 (95% CI: 1.2–2.4) for women. In conclusion, social isolation was associated with 60–70% increased mortality. Having no partner was associated with highest MRR.
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影响因子：
4
作者：
Thygesen SK;Christiansen CF;Christensen S;Lash TL;Sørensen HT
通讯作者：
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Adler, Nancy
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