Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis.
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis.
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DOI：
10.3390/ijms22041742
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发表时间：
2021-02-09
影响因子：
5.6
通讯作者：
Ecker M
中科院分区：
文献类型：
--
作者：
Hu Q;Ecker M
骨关节炎（Osteoarthritis，OA）是一种常见的退行性疾病，其特征在于关节软骨的破坏和周围组织的慢性炎症。基质金属蛋白酶-13（MMP-13）是通过其切割II型胶原的特定能力参与软骨降解的主要MMP。因此，它是治疗OA的有吸引力的靶点。然而，OA起始和进展的详细分子机制仍然难以捉摸，并且目前没有可用的干预措施来恢复退化的软骨。本文综述了MMP-13通过在分子水平和表观遗传水平上调节MMP-13的活性参与OA的发生和发展，以及针对MMP-13的策略。这篇综述的目的是确定MMP-13作为一个有吸引力的目标，抑制剂的发展，在治疗OA。
Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the treatment of OA. However, the detailed molecular mechanisms of OA initiation and progression remain elusive, and, currently, there are no interventions available to restore degraded cartilage. This review fully illustrates the involvement of MMP-13 in the initiation and progression of OA through the regulation of MMP-13 activity at the molecular and epigenetic levels, as well as the strategies that have been employed against MMP-13. The aim of this review is to identify MMP-13 as an attractive target for inhibitor development in the treatment of OA.
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