Neutrophils in type 1 diabetes.
Neutrophils in type 1 diabetes.
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DOI：
10.1111/jdi.12469
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发表时间：
2016-09
影响因子：
3.2
通讯作者：
Zhou Z
中科院分区：
文献类型：
--
作者：
Huang J;Xiao Y;Xu A;Zhou Z
1型糖尿病是一种自身免疫性疾病，困扰着全世界数百万人。它是由遗传和环境因素引发的产生胰岛素的胰腺β细胞破坏的结果。疾病的发生和发展涉及先天和适应性系统的β细胞和免疫细胞之间的复杂相互作用。免疫细胞，如T细胞，巨噬细胞和树突状细胞，已被充分证明在1型糖尿病发病机制中发挥关键作用。然而，作为最丰富的免疫细胞类型和对炎症反应的第一免疫细胞的嗜中性粒细胞在这种疾病的病因学中的特定作用可能确实被不公平地忽视了。过去几十年的进展表明，中性粒细胞可能对1型糖尿病的发生和持续有重要影响。中性粒细胞衍生的细胞毒性物质，包括在中性粒细胞成熟或活化过程中释放的脱粒产物、细胞因子、活性氧和细胞外陷阱，可导致胰岛细胞的破坏。此外，这些细胞可以启动致糖尿病T细胞反应，并通过与其他免疫和非免疫细胞的细胞间相互作用促进1型糖尿病的发展。此外，相关的抗神经营养素治疗已被证明可以延迟和抑制胰岛炎和自身免疫性糖尿病的进展。在此，我们从上述方面讨论中性粒细胞与自身免疫性1型糖尿病之间的关系，以更好地了解这些细胞在1型糖尿病的发生和发展中的作用。
Type 1 diabetes is an autoimmune disease that afflicts millions of people worldwide. It occurs as the consequence of destruction of insulin‐producing pancreatic β‐cells triggered by genetic and environmental factors. The initiation and progression of the disease involves a complicated interaction between β‐cells and immune cells of both innate and adaptive systems. Immune cells, such as T cells, macrophages and dendritic cells, have been well documented to play crucial roles in type 1 diabetes pathogenesis. However, the particular actions of neutrophils, which are the most plentiful immune cell type and the first immune cells responding to inflammation, in the etiology of this disease might indeed be unfairly ignored. Progress over the past decades shows that neutrophils might have essential effects on the onset and perpetuation of type 1 diabetes. Neutrophil‐derived cytotoxic substances, including degranulation products, cytokines, reactive oxygen species and extracellular traps that are released during the process of neutrophil maturation or activation, could cause destruction to islet cells. In addition, these cells can initiate diabetogenic T cell response and promote type 1 diabetes development through cell–cell interactions with other immune and non‐immune cells. Furthermore, relevant antineutrophil therapies have been shown to delay and dampen the progression of insulitis and autoimmune diabetes. Here, we discuss the relationship between neutrophils and autoimmune type 1 diabetes from the aforementioned aspects to better understand the roles of these cells in the initiation and development of type 1 diabetes.
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DOI：
10.1111/j.1365-2362.2004.01291.x
发表时间：
2004-01-01
影响因子：
5.5
作者：
Advani, A;Marshall, SM;Thomas, TH
通讯作者：
Thomas, TH
影响因子：
11.1
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通讯作者：
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影响因子：
64.8
作者：
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影响因子：
15.9
作者：
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通讯作者：
JANEWAY, CA
影响因子：
3.1
作者：
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通讯作者：
Lertmemongkolchai, Ganjana