Caveolin-1 and caveolae act as regulators of mitogenic signaling in vascular smooth muscle cells.
Caveolin-1 and caveolae act as regulators of mitogenic signaling in vascular smooth muscle cells.
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Caveolin-1 和 Caveolae 充当血管平滑肌细胞有丝分裂信号传导的调节剂。
DOI：
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
J. Thyberg
中科院分区：
文献类型：
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作者：
J. Thyberg
平滑肌细胞(SMCs)构成动脉壁的中层，通常是高度分化的收缩细胞，参与控制血压和血流。作为对血管损伤(物理或化学损伤)的反应，它们可能被激活，并获得通过组织迁移(从中层到内膜)、增殖和分泌细胞外基质成分的能力。这种分化特性的变化(从收缩表型到合成表型的转变)是SMC参与内膜增厚形成的先决条件，例如在动脉粥样硬化和再狭窄期间。1，2⇓最近也注意到在血液中循环的祖细胞渗透到损伤的内膜并引起病变SMC的可能性。3在这两种情况下，各种细胞外基质成分、生长因子和细胞因子发挥关键的调节作用。1，2⇓
参见第1521和1528页
最近，人们对小窝和小窝蛋白在控制细胞分化和增殖中的作用等方面的兴趣进一步迅速增长。4，5⇓小窝是50到80 nm的瓶状质膜内陷，富含胆固醇和鞘磷脂。它们含有膜蛋白小窝蛋白(描述了三种异构体)。小窝蛋白-1和-2存在于大多数细胞中，而小窝蛋白-3是肌肉特异性的(在骨骼肌和心肌细胞中表达最强)。小窝蛋白分子在膜上形成低聚物，并直接与胆固醇相互作用。因此，小窝蛋白和胆固醇都需要形成小窝特有的omega样形状。小窝蛋白还与许多信号分子相互作用(通过后者中的小窝蛋白结合基序)。5血小板衍生生长因子和表皮生长因子的受体及其信号链的主要下游成分只是几个例子。6-10⇓…
Smooth muscle cells (SMCs) build up the media of arterial walls and are normally highly differentiated, contractile cells that take part in the control of blood pressure and flow. In response to vascular injury (physical or chemical), they may become activated and gain the ability to migrate through the tissue (from the media to the intima), proliferate, and secrete extracellular matrix components. This change in differentiated properties (transition from a contractile to a synthetic phenotype) is a prerequisite for the participation of the SMCs in formation of intimal thickenings, eg, during atherosclerosis and restenosis.1,2⇓ Attention has lately also been paid to the possibility that progenitor cells circulating in the blood infiltrate the wounded intima and give rise to lesional SMCs.3 In both cases, a variety of extracellular matrix components, growth factors, and cytokines exert crucial regulatory roles.1,2⇓
See pages 1521 and 1528
Recently, a rapidly growing interest has further been focused on the function of caveolae and the protein caveolin in control of cell differentiation and proliferation, among others in the vascular system.4,5⇓ Caveolae are 50- to 80-nm, flask-shaped invaginations of the plasma membrane, enriched in cholesterol and sphingolipids. They contain the membrane protein caveolin (three isoforms described). Caveolin-1 and -2 are found in most cells, whereas caveolin-3 is muscle-specific (most strongly expressed in skeletal and heart muscle cells). The caveolin molecules form oligomers in the membrane and interact directly with cholesterol. Accordingly, both caveolin and cholesterol are required to give rise to the characteristic omega-like shape of caveolae. Caveolin also interacts with a multitude of signaling molecules (via a caveolin-binding motif in the latter).5 The receptors for platelet-derived growth factor (PDGF) and epidermal growth factor (EGF), and major downstream components in their signaling chains, are just a few examples.6–10⇓ …
DOI：
10.1056/nejm199906173402418
发表时间：
1999-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Williams Kj;I. Tabas
通讯作者：
Williams Kj;I. Tabas
影响因子：
6
作者：
Park, DS;Woodman, SE;Lisanti, MP
通讯作者：
Lisanti, MP
DOI：
10.1073/pnas.94.25.13666
发表时间：
1997-12-09
影响因子：
11.1
作者：
Liu, PS;Ying, YS;Anderson, RGW
通讯作者：
Anderson, RGW