Changes in mucociliary clearance over time in children with cystic fibrosis.
Changes in mucociliary clearance over time in children with cystic fibrosis.
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DOI：
10.1002/ppul.24858
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发表时间：
2020-09
影响因子：
3.1
通讯作者：
Mogayzel PJ Jr
中科院分区：
文献类型：
--
作者：
Laube BL;Carson KA;Evans CM;Richardson VL;Sharpless G;Zeitlin PL;Mogayzel PJ Jr
(1) To quantify changes in mucociliary clearance (MCC) over time in children with cystic fibrosis (CF) and the relationship between MCC and rate of infection with Pseudomonas aeruginosa (PA); (2) to determine the impact of MCC on the evolution of CF lung disease; and (3) to explore the role of mucus composition as a determinant of MCC. Children with CF, who had previously undergone an MCC measurement (Visit 1), underwent the following tests 3–10 years later: (1) second MCC measurement (Visit 2); (2) multiple breath washout to assess ventilation inhomogeneity, expressed as lung clearance index (LCI); (3) high resolution computed tomography lung scan (HRCT); and (4) induced sputum test. Number of PA+ cultures/year between visits was documented and mucus dry weight was quantified in the children and adult controls. Nineteen children completed both visits. Median time between visits was 4.6 years. Clearance declined 30% between visits. Lower MCC on Visit 2 was associated with more PA+ cultures/year between visits. Lower MCC values on Visit 1 were associated with higher LCI values and higher HRCT scores on Visit 2. Mucus dry weight was significantly higher in children with CF compared to controls. Higher dry weights were associated with lower MCC. Mucociliary clearance declines significantly over time in children with CF. The decline is associated with PA infection rate and is affected by mucus composition. Children with early slowing of MCC appear to be at risk for developing ventilation inhomogeneity and parenchymal lung damage when they are older.
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DOI：
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