Regulation of extraadrenal steroid 21-hydroxylase activity. Increased conversion of plasma progesterone to deoxycorticosterone during estrogen treatment of women pregnant with a dead fetus.
Regulation of extraadrenal steroid 21-hydroxylase activity. Increased conversion of plasma progesterone to deoxycorticosterone during estrogen treatment of women pregnant with a dead fetus.
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调节肾上腺外类固醇 21-羟化酶活性。
DOI：
10.1172/jci110471
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
ParkerJr,CR
中科院分区：
文献类型：
--
作者：
MacDonald,PC;Cutrer,S;MacDonald,SC;Casey,ML;ParkerJr,CR
我们测定了47例死胎孕妇血浆中的脱氧皮质酮（DOC）和孕酮（P），并在整个妊娠期间连续测定了35例活胎孕妇的血浆中的DOC和P。当血浆P水平低时，死胎孕妇血浆DOC水平变化，但通常与活胎孕妇相似。然而，当P水平高，DOC的水平在一些妇女怀孕的死胎大大低于妇女怀孕的活胎。为了检验这一发现是否是由于DOC从胎儿转移到母亲的损失或胎儿死亡后母亲肾上腺外类固醇21-羟化酶活性的损失，我们进行了几项研究。1例孕妇从胎儿死亡后30 min至分娩后13 h血浆P和DOC水平基本不变。雌激素治疗的四名妇女怀孕死胎带来了增加的DOC在三名妇女的血浆水平。在一名妇女的血浆DOC P的比例为0.015，一个值类似于胎儿死亡前发现，但胎儿死亡后，但雌激素治疗前为0.003。两名死胎孕妇的血浆P向DOC的转化常数在雌激素治疗前分别为0.011和0.005，在雌激素治疗期间分别为0.024和0.013。在一名妇女怀孕的畸形胎儿与肾上腺发育不全，代谢清除率的DOC前和雌激素治疗期间是相似的，而血浆生产率的DOC前和4.31毫克/24小时雌激素治疗期间。我们认为：（a）近足月孕妇血浆中DOC的产生部分是由于血浆P的肾上腺外21-羟化作用;（B）雌激素刺激肾上腺外组织中类固醇21-羟化酶的活性。
We measured deoxycorticosterone (DOC) and progesterone (P) in plasma of 47 women pregnant with a dead fetus and sequentially throughout gestation in 35 women pregnant with a live fetus. When P levels in plasma were low, the plasma levels of DOC in women pregnant with a dead fetus varied but usually were similar to those in women pregnant with a live fetus. However, when P levels were high, the levels of DOC in some women pregnant with a dead fetus were considerably lower than those in women pregnant with a live fetus. To test whether this finding was due to loss of transfer of DOC from fetus to mother or else loss of extraadrenal steroid 21-hydroxylase activity in the mother after death of the fetus, we conducted several studies. The levels of P and DOC in plasma of one woman remained constant from 30 min after fetal death until delivery occurred 13 h later. Estrogen treatment of four women pregnant with a dead fetus brought about an increase in plasma levels of DOC in three of the women. In one woman the ratio of plasma DOC to P was 0.015, a value similar to that found before fetal death, but was 0.003 after fetal death but before estrogen treatment. In two women pregnant with a dead fetus the transfer constants of conversion of plasma P to DOC were 0.011 and 0.005 before, and 0.024 and 0.013, respectively, during estrogen treatment. In one woman pregnant with a deformed fetus with adrenal agenesis, the metabolic clearance rates of DOC before and during estrogen treatment were similar, whereas the plasma production rates of DOC were 2.75 before and 4.31 mg/24 h during estrogen treatment. We suggest that (a) the DOC in plasma of near-term pregnant women arises in part by extraadrenal 21-hydroxylation of plasma P and (b) estrogen stimulates steroid 21-hydroxylase activity in extraadrenal tissues.
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影响因子：
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作者：
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DOI：
--
发表时间：
1966
期刊：
Acta Endocrinologica
影响因子：
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作者：
E. Bolté;N. Wiqvist;E. Diczfalusy
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DOI：
--
发表时间：
1978
期刊：
影响因子：
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作者：
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作者：
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DOI：
--
发表时间：
1976
期刊：
Perspectives in nephrology and hypertension
影响因子：
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作者：
E. N. Ehrlich;W. Nolten;S. Oparil;M. Lindheimer
通讯作者：
M. Lindheimer