Sustained modulation of primate deep brain circuits with focused ultrasonic waves.
Sustained modulation of primate deep brain circuits with focused ultrasonic waves.
复制标题
利用聚焦超声波对灵长类深部脑回路的持续调制。
DOI：
10.1016/j.brs.2023.04.012
复制
发表时间：
2023-05
影响因子：
7.7
通讯作者：
Kubanek, Jan
中科院分区：
文献类型：
--
作者：
Webb, Taylor D.;Wilson, Matthew G.;Odeen, Henrik;Kubanek, Jan
关键词：
经颅聚焦超声有可能无创地调节脑深部回路，并给予持续的神经可塑性效应。通过展示执行任务的非人类灵长类动物的深层脑回路和选择行为的持续调制，使方法更接近翻译。将持续时间为30秒的低强度经颅超声有控制地传递到非人类灵长类动物的脑深部目标（左或右外侧膝状核；LGN），同时受试者决定是先出现左侧还是先出现右侧视觉目标。当动物执行任务时，我们记录了枕骨螺钉的颅内脑电图。在6个多月的时间里，超声每天都被送到脑深部目标。短暂的刺激对选择行为的影响持续了15分钟，并且是特定于声音目标的。左/右LGN的刺激增加了向右/向左选择的比例。这些影响伴随着视觉皮层伽马活动的增加。与假刺激相比，对侧对选择行为的影响和伽马的增加表明，刺激激发了目标神经回路。在长达数月的刺激过程中，对动物的辨别能力没有不利影响。本研究表明，短暂的30秒超声刺激在目标脑深部回路中特异性地诱导神经可塑性效应，并且该刺激可以每天应用而不会产生有害影响。这些发现鼓励经颅超声反复应用于人类故障的深部脑回路，目的是提供持久的治疗重置。
Transcranial focused ultrasound has the potential to noninvasively modulate deep brain circuits and impart sustained, neuroplastic effects. Bring the approach closer to translations by demonstrating sustained modulation of deep brain circuits and choice behavior in task-performing non-human primates. Low-intensity transcranial ultrasound of 30 s in duration was delivered in a controlled manner into deep brain targets (left or right lateral geniculate nucleus; LGN) of non-human primates while the subjects decided whether a left or a right visual target appeared first. While the animals performed the task, we recorded intracranial EEG from occipital screws. The ultrasound was delivered into the deep brain targets daily for a period of more than 6 months. The brief stimulation induced effects on choice behavior that persisted up to 15 minutes and were specific to the sonicated target. Stimulation of the left/right LGN increased the proportion of rightward/leftward choices. These effects were accompanied by an increase in gamma activity over visual cortex. The contralateral effect on choice behavior and the increase in gamma, compared to sham stimulation, suggest that the stimulation excited the target neural circuits. There were no detrimental effects on the animals’ discrimination performance over the months-long course of the stimulation. This study demonstrates that brief, 30-s ultrasonic stimulation induces neuroplastic effects specifically in the target deep brain circuits, and that the stimulation can be applied daily without detrimental effects. These findings encourage repeated applications of transcranial ultrasound to malfunctioning deep brain circuits in humans with the goal of providing a durable therapeutic reset.
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