Radiobiological assessment of permanent implants using tumour repopulation factors in the linear-quadratic model.
Radiobiological assessment of permanent implants using tumour repopulation factors in the linear-quadratic model.
复制标题
在线性二次模型中使用肿瘤再增殖因子对永久植入物进行放射生物学评估。
作者：
R. Dale
通过将与衰变源治疗相关的现有线性二次方程与假定的肿瘤再生因子相结合，可以设计出一种对永久植入物进行放射生物学评估的方法。出于计算目的，存在一段时间，在此之后植入物不能再被认为能够有效地杀死肿瘤细胞。永久植入物的这种“有效”治疗时间可以根据放射性核素衰变常数、潜在倍增时间、初始剂量率和肿瘤α/β比率中的α值来近似定义。该分析技术已应用于使用 125I 和 198Au 的常见植入物的具体比较，并表明，即使在最有利的情况下，前一种放射性核素也几乎没有提供放射生物学优势。尽管这里没有具体讨论，但该方法也可应用于评估各种形式的生物靶向放射治疗。
By combining existing linear-quadratic equations relating to decaying-source therapy with an assumed tumour repopulation factor, it has been possible to devise a method for the radiobiological assessment of permanent implants. For calculation purposes there is a time after which an implant can no longer be considered effective in sterilizing tumour cells. This "effective" treatment time for a permanent implant can be approximately defined in terms of the radionuclide decay constant, the potential doubling time, the initial dose-rate and the value of alpha in the tumour alpha/beta ratio. The analytical technique has been applied to a specific intercomparison of commonly encountered implants using 125I and 198Au, and suggests that, even in the most favourable cases, the former radionuclide offers few radiobiological advantages. Although not specifically discussed here, the method can also be applied to the assessment of various forms of biologically targeted radiotherapy.
DOI：
10.1259/0007-1285-60-714-573
发表时间：
1987-06
期刊：
The British journal of radiology
影响因子：
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作者：
M. Marchese;M. Zaider;E. Hall
通讯作者：
M. Marchese;M. Zaider;E. Hall