Stress-induced biological aging: A review and guide for research priorities.
Stress-induced biological aging: A review and guide for research priorities.
复制标题
DOI：
10.1016/j.bbi.2022.05.016
复制
发表时间：
2022-08
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
暴露于慢性不利条件下，以及由此产生的神经生物学反应级联激活，与年龄相关疾病早发风险增加有关，最近，与生物年龄增加有关。这一研究机构提出了一个假设，即反复或长时间暴露于压力生活体验中可能会加速身体衰老的速度。慢性心理社会压力影响不同生物衰老途径以改变衰老速率的机制可能涉及生理分子网络中的多个层。在这篇综述中，我们整合了使用动物，人类和体外模型的研究，开始描绘慢性心理社会应激可能影响生物衰老的不同途径，以及神经内分泌介质（即，去甲肾上腺素、肾上腺素和糖皮质激素），其可驱动这些效应。研究结果强调了压力和衰老之间的关键联系，即细胞代谢活动，DNA损伤，端粒长度，细胞衰老和炎症反应模式。最后，我们总结了一个指导框架和概念模型，概述了最有希望的生物学途径，通过这些途径，慢性不利条件可能会加速衰老，并指出未来研究可以最好地回答这些紧迫问题的知识中的关键缺失空白。
Exposure to chronic adverse conditions, and the resultant activation of the neurobiological response cascade, has been associated with an increased risk of early onset of age-related disease and, recently, with an older biological age. This body of research has led to the hypothesis that exposure to stressful life experiences, when occurring repeatedly or over a prolonged period, may accelerate the rate at which the body ages. The mechanisms through which chronic psychosocial stress influences distinct biological aging pathways to alter rates of aging likely involve multiple layers in the physiological-molecular network. In this review, we integrate research using animal, human, and in vitro models to begin to delineate the distinct pathways through which chronic psychosocial stress may impact biological aging, as well as the neuroendocrine mediators (i.e., norepinephrine, epinephrine, and glucocorticoids) that may drive these effects. Findings highlight key connections between stress and aging, namely cellular metabolic activity, DNA damage, telomere length, cellular senescence, and inflammatory response patterns. We conclude with a guiding framework and conceptual model that outlines the most promising biological pathways by which chronic adverse conditions could accelerate aging and point to key missing gaps in knowledge where future research could best answer these pressing questions.
登录
查看更多内容
影响因子：
5.2
作者：
Black DS;Slavich GM
通讯作者：
Slavich GM
影响因子：
4.3
作者：
Bagchi, D;Carryl, OR;Stohs, SJ
通讯作者：
Stohs, SJ
DOI：
10.1073/pnas.0911515107
发表时间：
2010-03-23
影响因子：
11.1
作者：
Cole, Steven W.;Arevalo, Jesusa M. G.;Seeman, Teresa E.
通讯作者：
Seeman, Teresa E.
影响因子：
4
作者：
Ahmed, Shaheda;Passos, Joao F.;Saretzki, Gabriele
通讯作者：
Saretzki, Gabriele
影响因子：
8.8
作者：
Aninat, Caroline;Seguin, Philippe;Guillouzo, Andre
通讯作者：
Guillouzo, Andre