Use and efficacy of bone morphogenetic proteins in fracture healing.
Use and efficacy of bone morphogenetic proteins in fracture healing.
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DOI：
10.1007/s00264-011-1301-z
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发表时间：
2011-09
影响因子：
2.7
通讯作者：
Schipper, Inger B.
中科院分区：
文献类型：
--
作者：
Lissenberg-Thunnissen, Suzanne N.;de Gorter, David J. J.;Sier, Cornelis F. M.;Schipper, Inger B.
这篇综述评估了骨形态发生蛋白（BMPs）在延迟骨修复中的应用，针对从临床医生到科学家的广泛受众。除了概述不同bmp的作用、它们的拮抗剂和它们目前的应用外，还特别关注了提高bmp为基础的骨修复治疗效果的新科学进展。在PubMed和Embase上的出版物搜索显示850篇关于“BMP”和“骨修复”标准的相关文章（截至2011年5月）。对摘要进行了仔细的审查，并根据内容选择论文。由此产生的出版物表明，BMP-2和BMP-7显然是最广泛评估的bmp，通常在骨愈合方面具有积极的结果，可与使用非特异性制剂（如自体骨移植或富血小板血浆）相媲美。尽管BMPs作为骨修复刺激剂的功效已在模型系统和临床研究中得到证实，但在临床环境中使用BMPs来促进骨折愈合仍存在争议。诸如何时、何地以及在多大程度上使用BMP是最有效和最有利的等问题仍有待阐明。但是，在不久的将来，BMP产品的优化与更便宜的生产方法相结合，将不可避免地促进BMP在骨折愈合中的临床应用。
This review evaluates the application of bone morphogenetic proteins (BMPs) in delayed bone repair, aiming at a broad audience from clinicians to scientists. Next to an overview of the role of the different BMPs, their antagonists and their current applications, special attention is focused on new scientific developments improving the effects of BMP-based therapy for bone repair. Publication searches in PubMed and Embase revealed 850 relevant articles on the criteria ‘BMP’ AND ‘bone repair’ (as of May 2011). The abstracts were carefully reviewed and papers were selected according to the content. The resulting publications showed that BMP-2 and BMP-7 are clearly the most extensively evaluated BMPs, in general with positive results on bone healing, comparable to the use of unspecific preparations such as autologous bone grafts or platelet-rich plasma. Although the efficacy of BMPs as stimulators of bone repair has been demonstrated in model systems and clinical studies, the use of BMPs to enhance fracture healing in the clinical setting is still controversial. Issues such as when, where and how much of which BMP is the most effective and profitable to use still have to be elucidated. But optimisation of the BMP products used in combination with cheaper production methods will inevitably stimulate the clinical use of BMPs for bone fracture healing in the near future.
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影响因子：
3.4
作者：
Feiner N;Begemann G;Renz AJ;Meyer A;Kuraku S
通讯作者：
Kuraku S
影响因子：
4.4
作者：
DiLeone, RJ;King, JA;Kingsley, DM
通讯作者：
Kingsley, DM
影响因子：
2.5
作者：
Gamer, Laura W.;Cox, Karen;Carlo, Joelle M.;Rosen, Vicki
通讯作者：
Rosen, Vicki
影响因子：
1.8
作者：
Chen, D;Zhao, M;Mundy, GR
通讯作者：
Mundy, GR
影响因子：
6.2
作者：
Cho, TJ;Gerstenfeld, LC;Einhorn, TA
通讯作者：
Einhorn, TA