Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study.
Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study.
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DOI：
10.1289/ehp.0900572
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发表时间：
2009-11
影响因子：
10.4
通讯作者：
Laden F
中科院分区：
文献类型：
--
作者：
Puett RC;Hart JE;Yanosky JD;Paciorek C;Schwartz J;Suh H;Speizer FE;Laden F
细颗粒物< 2.5 μm直径（PM2.5）空气污染与死亡率和心血管疾病的关系已得到很好的确立，最近的长期研究报告的效应值比早期的长期研究更大。一些研究表明，2.5到10 μm之间的粗颗粒（PM10-2.5）可能也很重要。关于死亡率和心血管事件，关于长期暴露于细颗粒和粗颗粒的效应大小的相对强度的问题仍然存在。我们研究了慢性PM2.5和PM10-2.5暴露与全因死亡率以及致死性和非致死性冠心病（CHD）的关系，并对时变协变量进行了调整。目前的研究包括来自护士健康研究的女性，她们生活在美国东北部和中西部的大都市地区。随访时间为1992年至2002年。我们使用基于地理信息系统的空间平滑模型来估计每个参与者每月在住所的暴露量。我们发现全因死亡风险增加[危险比（HR）， 1.26；95%可信区间（CI）， 1.02-1.54]和致死性冠心病（HR = 2.02; 95% CI, 1.07-3.78）与PM2.5年暴露量每增加10 μg/m3相关。致死性冠心病与PM10-2.5的相关性较弱。我们的发现为慢性PM2.5暴露与全因死亡率和心血管死亡率相关的证据提供了证据。
The relationship of fine particulate matter < 2.5 μm in diameter (PM2.5) air pollution with mortality and cardiovascular disease is well established, with more recent long-term studies reporting larger effect sizes than earlier long-term studies. Some studies have suggested the coarse fraction, particles between 2.5 and 10 μm (PM10–2.5), may also be important. With respect to mortality and cardiovascular events, questions remain regarding the relative strength of effect sizes for chronic exposure to fine and coarse particles. We examined the relationship of chronic PM2.5 and PM10–2.5 exposures with all-cause mortality and fatal and nonfatal incident coronary heart disease (CHD), adjusting for time-varying covariates. The current study included women from the Nurses’ Health Study living in metropolitan areas of the northeastern and midwestern United States. Follow-up was from 1992 to 2002. We used geographic information systems–based spatial smoothing models to estimate monthly exposures at each participant’s residence. We found increased risk of all-cause mortality [hazard ratio (HR), 1.26; 95% confidence interval (CI), 1.02–1.54] and fatal CHD (HR = 2.02; 95% CI, 1.07–3.78) associated with each 10-μg/m3 increase in annual PM2.5 exposure. The association between fatal CHD and PM10–2.5 was weaker. Our findings contribute to growing evidence that chronic PM2.5 exposure is associated with risk of all-cause and cardiovascular mortality.
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影响因子：
37.8
作者：
Pope, CA;Burnett, RT;Godleski, JJ
通讯作者：
Godleski, JJ
影响因子：
10.4
作者：
Lipsett MJ;Tsai FC;Roger L;Woo M;Ostro BD
通讯作者：
Ostro BD
影响因子：
1.8
作者：
Paciorek, Christopher J.;Yanosky, Jeff D.;Suh, Helen H.
通讯作者：
Suh, Helen H.
影响因子：
3.8
作者：
Becker, Susanne;Mundandhara, Sailaja;Madden, Michael
通讯作者：
Madden, Michael
影响因子：
120.7
作者：
Dominici, F;Peng, RD;Samet, JM
通讯作者：
Samet, JM