Coarse particles and heart rate variability among older adults with coronary artery disease in the Coachella Valley, California.
Coarse particles and heart rate variability among older adults with coronary artery disease in the Coachella Valley, California.
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DOI：
10.1289/ehp.8856
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发表时间：
2006-08
影响因子：
10.4
通讯作者：
Ostro BD
中科院分区：
文献类型：
--
作者：
Lipsett MJ;Tsai FC;Roger L;Woo M;Ostro BD
通过心率变异性 (HRV) 的变化来评估心脏自主控制的改变，为接触空气颗粒物 (PM) 与心血管死亡风险增加之间的一致关联提供了一种合理的机制解释。 HRV 降低与接触 PM10（空气动力学直径 ≤ 10 μm 的 PM）和主要源自燃烧源的细颗粒（空气动力学直径 ≤ 2.5 μm 的 PM）有关。然而，人们对 HRV 和粗颗粒 [空气动力学直径为 10–2.5 μm (PM10–2.5)] 之间的关系知之甚少，粗颗粒通常是由灰尘和土壤夹带或工业和运输中的机械研磨过程造成的。我们测量了居住在加利福尼亚州科切拉山谷的 19 名患有冠状动脉疾病的不吸烟老年人的几个 HRV 变量，该山谷是一个沙漠度假胜地和退休区，周围的 PM10 主要由 PM10-2.5 组成。 2000 年春季，研究对象每周佩戴一次动态心电图监测仪 24 小时，持续长达 12 周。污染物浓度在附近的固定地点监测仪上进行评估。我们使用控制个体特定影响的混合模型来检查空气污染物和几个 HRV 指标之间的关系。 HRV 多项指标的下降与 PM10 和 PM10-2.5 一致相关；然而，HRV 变量与 PM2.5 浓度几乎没有关系。相关性的大小（PM10 或 PM10-2.5 每增加 10 μg/m3，HRV 下降约 1-4%）与其他几项 PM 研究中观察到的结果相当。环境 PM10-2.5 水平升高可能会对患有冠状动脉疾病的老年受试者的 HRV 产生不利影响。
Alterations in cardiac autonomic control, assessed by changes in heart rate variability (HRV), provide one plausible mechanistic explanation for consistent associations between exposure to airborne particulate matter (PM) and increased risks of cardiovascular mortality. Decreased HRV has been linked with exposures to PM10 (PM with aerodynamic diameter ≤ 10 μm) and with fine particles (PM with aerodynamic diameter ≤ 2.5 μm) originating primarily from combustion sources. However, little is known about the relationship between HRV and coarse particles [PM with aerodynamic diameter 10–2.5 μm (PM10–2.5)], which typically result from entrainment of dust and soil or from mechanical abrasive processes in industry and transportation. We measured several HRV variables in 19 nonsmoking older adults with coronary artery disease residing in the Coachella Valley, California, a desert resort and retirement area in which ambient PM10 consists predominantly of PM10–2.5. Study subjects wore Holter monitors for 24 hr once per week for up to 12 weeks during spring 2000. Pollutant concentrations were assessed at nearby fixed-site monitors. We used mixed models that controlled for individual-specific effects to examine relationships between air pollutants and several HRV metrics. Decrements in several measures of HRV were consistently associated with both PM10 and PM10–2.5; however, there was little relationship of HRV variables with PM2.5 concentrations. The magnitude of the associations (~ 1–4% decrease in HRV per 10-μg/m3 increase in PM10 or PM10–2.5) was comparable with those observed in several other studies of PM. Elevated levels of ambient PM10–2.5 may adversely affect HRV in older subjects with coronary artery disease.
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影响因子：
5.4
作者：
Holguin, F;Téllez-Rojo, MM;Romieu, I
通讯作者：
Romieu, I
影响因子：
2.8
作者：
HAYANO, J;YAMADA, M;TAKATA, K
通讯作者：
TAKATA, K
影响因子：
9.9
作者：
KUROIWA, Y;SHIMADA, Y;TOYOKURA, Y
通讯作者：
TOYOKURA, Y
影响因子：
8.3
作者：
Ostro, BD;Hurley, S;Lipsett, MJ
通讯作者：
Lipsett, MJ
影响因子：
10.4
作者：
Liao, DP;Creason, J;Zweidinger, R
通讯作者：
Zweidinger, R